Bioinformatics Postdoctoral Associate
Laboratory of Genome Maintenance at the Rockefeller University (Agata Smogorzewska, PI) is interested in how DNA repair defect stimulates cancer development. Through analysis of germline and somatic variants in patient samples, we aim to understand tumor genetic landscape and how it influences the biology of tumors that develop in Fanconi anemia patients.
We are seeking a highly talented, innovative, and motivated computationally oriented postdoctoral scientist to develop and direct the computational analyses of genetic defects in Fanconi anemia germline and tumors from whole-genome, whole-exome and transcriptome sequencing datasets. The postdoctoral scientist will work in close collaboration with the Laboratory of Olivier Elemento, Cancer Systems Biology at Weill Cornell Medical School.
Competitive applicants will have a PhD in bioinformatics, biostatistics, genomics, or similar field, with experience and publications in analysis of next-generation sequencing data including mutational analysis. They will be proficient in relevant programming languages such as Python, Perl, Linux, R/Bioconductor and C++. Familiarity with deep sequencing analysis tools such as Strelka, Mutect, Varscan, BreakDancer, TopHat, STAR, CuffLinks etc is a requirement. Competitive applicants will also have strong communication skills in spoken and written English, with a proven record of working well in team environments.
Interested individuals should send a CV and the names of three references to Dr. Smogorzewska (firstname.lastname@example.org with a subject line “Bioinformatics postdoc position”). Applications will be accepted until the position is filled. The position is available starting Fall 2014.
Postdoctoral position in Immune Cell Epigenetics and Signaling
The Laboratory of Immune Cell Epigenetics and Signaling at The Rockefeller University, New York, NY is searching for an outstanding postdoctoral researcher interested in studying the epigenetic control of B cell differentiation and myelomagenesis. The project will investigate the role of methyltransferase MMSET/NSD1 in transcriptionalcontrol of early B cell differentiation, primordial lymphopoiesis and malignant transformation of plasma lineage cells. The project will utilize mouse mutants with conditional inactivation or overexpression of MMSET that are readily available for the studies. The postdoctoral researcher will play a key role in our effort to understand rules that govern transcriptional diversification of primordial and adult B cell lymphopoiesis, including immunoglobulin gene rearrangement and B cell survival. Candidates must have a strong background in B cell immunology and mouse genetics, and familiarity with basic principles of gene regulation. Applicants with strong quantitative skills are particularly encouraged to apply. Interested candidates should send their curriculum vitae; and a description of their scientific interest including the names and contact information of three professional references to email@example.com. Please include in the Subject Line: Application for Postdoctoral Opportunity - Epigenetic control of B cell differentiation and myelomagenesis.
The position is available immediately.Applications will be accepted until the position is filled. The position is available immediately.
Postdoctoral position in Immune Cell Epigenetics and Signaling
The Laboratory of Immune Cell Epigenetics and Signaling at The Rockefeller University, New York, NY is searching for an outstanding postdoctoral researcher interested in studying the epigenetic control of immune cell diversification and adaptation. The project will investigate the single cell diversity of epigenetic regulation and tackle the role of specific epigenetic regulators that control the process. The project will utilize mouse immunology, the CRISPR mediated gene modification and chromatin studies. The postdoctoral researcher will play a key role in our effort to understand rules that govern transcriptional cell diversification. Candidates must have a strong background in immunology and be familiar with basic principles of gene regulation. Applicants with strong quantitative skills are particularly encouraged to apply. Interested candidates should send their curriculum vitae; and a description of their scientific interest including the names and contact information of three professional references to firstname.lastname@example.org. Please include in the Subject Line: Application for Postdoctoral Opportunity - Epigenetic control of immune cell diversification and adaptation.
The position is available immediately. Applications will be accepted until the position is filled. The position is available immediately.
Postdoctoral position in Neuroscience: Neuroscience of Knowledge
The Laboratory of Systems Neuroscience at The Rockefeller University, New York, NY, is searching for an outstanding postdoctoral researcher interested in studying the neural basis of conceptual knowledge. The project will investigate the circuits and single cell mechanisms by which we represent knowledge about the world, in particular about familiar individuals. We will build on our extensive knowledge about face-recognition networks and the discovery of concept cells (e.g., the Jennifer-Aniston cell) in human hippocampus. The project will utilize functional magnetic resonance imaging in combination with electrophysiology and behavioral testing, and is embedded into an HFSP-sponsored collaborative research team for cross-species comparisons of concept representations (with Rodrigo Quian Quiroga, Mathew Diamond, and Davide Zoccolan) and theoretical and computational modeling (with Haim Sompolinsky). The postdoctoral researcher will play a key role in our effort to understand how conceptual representations of persons, which are key for memory functions, are formed from representations in high level face-processing areas. Candidates should, ideally, have a strong background in temporal lobe physiology or other scientific experience relevant to the project, strong quantitative skills, a record of scientific productivity, and a desire to understand memory systems, and be interested to work both independently and as part of a team. Interested candidates should send their curriculum vitae, a description of their scientific interest together with the names and the contact information of three professional references to email@example.com.
Postdoctoral position in Computational Biostatistics
A postdoctoral position in computational biostatistics is available at the Rockefeller University’s CTSA-supported Center for Clinical and Translational Science in the Biostatistics, Epidemiology, and Research Design (BERD) group. The successful candidate will collaborate extensively with investigators in the Center in design and analysis of a wide range of research projects, with a special emphasis on developing new statistical methods for analysis of genomic results in Genome Wide Association Studies (GWAS) and Genome-Wide Expression Studies (GWES).
GWAS and GWES have had limited success when applied to complex diseases. Analyzing SNPs or genes individually requires several large studies to integrate the often divergent results. Traditional parametric approaches for multivariate data often have low sensitivity and generate an abundance of artifacts, while non-parametric approaches have never been fully developed, due to their high computational demand. At the RU BERD, we have extended u-statistics (Hoeffding 1948, Gehan 1965) to include information about the sequence of neighboring SNPs and information from the HapMap project about recombination hotspots (GWAS) as well as collaboration across binding sites and along pathways (GWES) to increase the power and/or reduce sample size requirements. To make these approaches feasible, we have built a grid infrastructure and developed algorithms to harness the power of graphics processing units for general purpose computing (GP2U). For publications, including applications to psoriasis (Stat Med 2004), addiction (Mol Brain Res 2004), Fanconi Anemia (SAGMB 2008), and multiple sclerosis (BMC Med Genet 2009), as well as sports (JQAS 2008) and consumer preferences (Transportation 2009), see https://appext.rockefeller.edu/facpub/do/query_pub_list?author1=wittkowski. Current projects include collaborations cancer and immunology (Krueger Lab), as well as epilepsy (Mount Sinai School of Medicine), multiple sclerosis (OxfordUniversity), and myocardial infarction (HarvardUniversity).
We are seeking a highly motivated individual who is interested in applying a whole range of statistical and computational approaches, including further work on u-statistics for multivariate data, development of massively parallel algorithms, implementation in OpenCL, and integration into a Web interface to a grid-based architecture to support clinical and translational research in these exciting times, where the computational biostatistics approaches being developed revolutionize diagnostic and therapeutic strategies.
The Rockefeller University supports a vibrant and growing research community in genetics and the successful candidate will have the opportunity to interact with leading researchers in the field. No teaching is required.
A Ph.D. in statistics or computer science or equivalent is required. Ability to think and work rigorously and skeptically, strong desire to solve problems in translational science, willingness to learn new subjects are essential, as is the ability to communicate efficiently in both spoken and written English. Additional background in biology, genetics, medicine, and related fields is desirable.
The ideal candidate for the position will have a strong background in non-parametric statistics, knowledge of php, SQL, S+/R, C, OpenCL/CUDA, and a record of successfully developed Web-based applications.
Applications will be accepted until the position is filled. The position is available immediately.
To apply, please submit the following items to Dr. Knut M. Wittkowski at: firstname.lastname@example.org: CV, contact information for two to three references, a short cover letter (not more than one page) describing your background and research interests.
Postdoctoral position in Investigative Dermatology
A two-three year postdoctoral position is available in the Laboratory of Investigative Dermatology at Rockefeller University, working with Drs. Emma Guttman and James Krueger. The research will involve studying the immune and barrier abnormalities underlying atopic dermatitis, as well as the reversal of atopic dermatitis disease with several novel biologic therapies targeting main immune axes involved in the disease that might revolutionize treatment of atopic dermatitis, and understanding of the disease. The postdoc is truly translational in its nature. The work will be a collaboration between Mount Sinai Dermatology and Immunology Institute and the Rockefeller University, but the laboratory portion will be mainly done at the Rockefeller University, although the position will be paid by Mount Sinai or from a collaborative grant between the institutions.
The Laboratory of Investigative Dermatology is an established lab at the Rockefeller University campus on Manhattan's Upper East Side. The Mount Sinai Immunology Institute and dermatology departments are also located on the Upper East Side. Dr. Guttman is an expert in atopic dermatitis research and her research identified a novel T-cell subset in humans, T22, that hold a potential therapeutic promise for this disease. For this discovery, and the promise it holds for advancing treatments for atopic eczema, a disease affecting many patients worldwide, Dr. Guttman received the Young Investigator Award of the American Academy of Dermatology.
The ideal candidate for the position will have a strong background in immunology, as well as an interest in dermatology, and atopic dermatitis/eczema in particular, and want to participate in this exciting time with the potential of revolutionizing the known pathways and treatments for this disease. Experience in flow cytometry, tissue culture, molecular biology and immunohistochemistry preferred. Strong publications from Ph.D. are highly preferred.
Applications will be accepted until the position is filled. The position is available immediately.
To apply, please submit the following items to Dr Emma Guttman at: email@example.com
- Contact information for two to three references
- A short cover letter describing your background and research interests (not more than one page)
Postdoctoral Position in the Mechanisms of pre-mRNA Splicing
We are looking for an individual with a strong interest in mechanistic studies of macromolecular complexes, RNP structure and function, and nucleic acid-protein interactions. The project concerns characterization of exon sequence motifs that act as yeast splicing enhancers by affecting substrate interactions with the spliceosome and altering catalytic steps.
The ideal candidate would have experience working with yeast or with RNA/protein complexes and a strong background in biochemistry, molecular biology, or genetics. The desire to think and design experiments independently is also required. Please send a CV and statement of research interest to:
with: postdoc_Your Name in the subject line.
Postdoctoral Associate in the Laboratory of Populations
The Laboratory of Populations, headed by Joel E. Cohen, seeks to hire a Postdoctoral Associate to begin between September 30, 2010, and late summer 2011. The successful applicant will do full-time research on mathematical, statistical, and empirical questions in population biology. A main focus is the relationship between the average and the variance of population sizes, including Taylor's Law. Empirical examples to be studied will include microbes, trees, and people. Additional topics in population- and community-level biology include population dynamics, food webs, infectious diseases, human mortality, and other topics of interest to the Associate and the Lab. For more information about the Lab's research, see http://lab.rockefeller.edu/cohenje/. For publications, see http://lab.rockefeller.edu/cohenje/pubvita.
A Ph.D. in mathematics or statistics, or exceptionally strong quantitative training in mathematics or statistics as part of a Ph.D. in a quantitative science, is required. Ability to think rigorously and skeptically, strong desire to solve problems in population biology, willingness to learn new subjects, and willingness to give and take criticism with good humor are essential. An ability to write clear English is essential. Experience in writing, testing, and documenting computer programs clearly is essential. Additional background in ecology, population biology, physics, computer science and related fields is desirable.
First year's salary for a new doctorate is $46,000. The salary increases with seniority and with prior experience in accordance with University guidelines. Depending on performance, the position will last one to five years. Initial funding is provided by a grant from the U.S. National Science Foundation. No teaching is required.
The Rockefeller University, a leading center of biological research in New York City, is a culturally diverse institution in a culturally diverse city. Approximately half of the faculty and students at The Rockefeller University are not of United States origin. An appetite for cultural diversity in daily contacts is essential. We collaborate extensively with colleagues elsewhere in the United States and abroad. New York is home to several other institutions pursuing research in population biology, including Columbia University, New York University and the Population Council. The Associate may participate in the Earth Institute Fellows Program at Columbia University by mutual agreement of the Associate and that Program.
For more information, contact Joel E. Cohen at firstname.lastname@example.org. Do not telephone. To apply, send to Priscilla K. Rogerson at email@example.com two documents (in .txt, .pdf, .doc, or .docx format) as email attachments: a cover letter summarizing your mathematical, statistical and scientific experience, interests and goals (at most two pages single-spaced); and a vita, including a list of publications and the names, email addresses and telephone numbers of three references. Do not request that letters of reference be sent. Do include your family name followed by given name at the beginning of the file name of each attached document.
Research Associate/Bioinformatician in Chromatin Analyses
Seeking skilled Ph.D. with expertise in computer analyses of ChIP-seq and microarray data interested in working with a research team conducting molecular biology on epithelial stem cells. Must be trained in computer programming and handling large data sets.
Please send curriculum vitae and statement of research interest to firstname.lastname@example.org.
Rockefeller University NIH CTSA KL2 Clinical Scholars Program
Post Fellowship Patient-Oriented Research Training for Physician-Scientists
The CTSA-supported KL2 Clinical Scholars Program is a three-year Master's degree program with fully protected time designed to provide an optimal environment for physician-scientists starting a career in patient-oriented research. It combines focused research on a project involving human subjects under the direction of a senior Rockefeller University mentor with a comprehensive tutorial-based curriculum in patient-oriented research led by Dr. Barry Coller, Physician-in-Chief. See http://www.rockefeller.edu/ccts/training/KL2program for details. Salary and benefits are competitive.
Please apply on-line at http://scholarapplication.rockefeller.edu/. For additional information contact Dr. Barry Coller; Laboratory of Blood and Vascular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065.
The University provides reasonable accommodations to qualified individuals with disabilities who can perform the essential functions for the position. If you require a reasonable accommodation for any part of the application and/or hiring process, please notify Human Resources by calling 212-327-8300 or emailing email@example.com.
The Rockefeller University is an Equal Opportunity Employer with a policy that forbids discrimination in employment for protected characteristics. The Administration has an Affirmative Action Program to increase outreach to women, minorities, individuals with disabilities, and protected veterans.