Fisher Drug Discovery Resource Center
We are a leading academic hub for early-stage drug discovery, empowering the next generation of scientists to drive therapeutic innovation. By combining rigorous scientific training with cutting-edge resources, we aim to remove barriers to discovery, streamline research processes, and foster breakthroughs that contribute to the development of novel treatments. Through collaboration, state-of-the-art technologies, and a commitment to scientific excellence, we seek to make a lasting impact on drug discovery.
We train our scientists through hands-on research focused on the early stages of drug development. By integrating fundamental medical science with practical experience, we equip trainees with the expertise to identify and optimize compounds that precisely target molecular pathways. Our center emphasizes key early discovery processes—from hit identification to lead optimization—fostering a deep molecular understanding of the mechanisms of action of drugs.
We provide our trainees with access to a diverse collection of 635,000 drug-like compounds, cutting-edge lab automation, and state-of-the-art bioassay technologies. Through the study of drug-target interactions we enable researchers to refine bioassays, identify promising compounds, and optimize early-stage compounds efficiently.
(RRID:SCR_020985)
The DDRC supports these technologies:
-
- high throughput screening
- high content screening
- fragment-based screening
- surface plasmon resonance
- isothermal titration calorimetry
- automated pipetting
- LICOR
- microscale thermophoresis (standard and label-free)
- Dynamic Light Scattering
- Fluorescence Resonance Energy Transfer ( time-gated and non-gated)
- AlphaLisa and AlphaScreen (luminescence oxygen channeling)
- HPLC-TOF Mass Spectrometry (reverse phase, analytical scale)
- temperature-related fluorescence intensity change
- Circular Dichroism
- Digital PCR
- SeaHorse Metabolic Analysis
- Scintillation Proximity
- FPLC
- Fluorescence kinetics microplate imaging
- Spectral shift analysis
- Cheminformatics
Fisher Drug Discovery Resource Center Lecture, June 5, 2024
Meeting Recording Here(opens in new window)
