Publications

Ahn HJ, Glickman JF, Poon KL, Zamolodchikov D, Jno-Charles OC, Norris EH, Strickland S. (2014) A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice. J Exp Med.  May 12. [Epub ahead of print] PubMed PMID: 24821909.

Gasque G, Conway S, Huang J, Rao Y, Vosshall LB. (2013) Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target. SciRep. 2013;3:srep02120. doi: 10.1038/srep02120. PubMed PMID: 23817146; PubMedCentral PMCID: PMC3698492

Solmaz SR, Blobel G, Melcák I. Ring cycle for dilating and constricting the nuclear pore. (2013) Proc Natl Acad Sci U S A. Apr 9;110(15):5858-63. doi:10.1073/pnas.1302655110. Mar 11. PubMed PMID: 23479651; PubMed Central PMCID: PMC3625290.

Chang CY, Pasolli HA, Giannopoulou EG, Guasch G, Gronostajski RM, Elemento O, Fuchs E. (2013) NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche. Nature. 2013 Mar 7;495(7439):98-102. doi: 10.1038/nature11847. Epub 2013 Feb 6. PubMed PMID: 23389444; PubMed Central PMCID: PMC3635831.

Petrova E, Rios-Esteves J, Ouerfelli O, Glickman JF, Resh MD. Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. (2013) Nat Chem Biol. 2013 Apr;9(4):247-9. doi: 10.1038/nchembio.1184. Feb 17. PubMed PMID: 23416332; PubMed Central PMCID: PMC3604071.

Mellén M, Ayata P, Dewell S, Kriaucionis S, Heintz N. MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. (2012) Cell. Dec 21;151(7):1417-30. doi: 10.1016/j.cell.2012.11.022. PubMed PMID: 23260135.

Glickman JF. Assay Development for Protein Kinase Enzymes. 2012 May 01 [updated 2012 Oct 01]. In: Sittampalam GS, Gal-Edd N, Arkin M, Auld D, Austin C, Bejcek B, Glicksman M, Inglese J, Lemmon V, Li Z, McGee J, McManus O, Minor L, Napper A, Riss T, Trask OJ, Weidner J, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-. Available from http://www.ncbi.nlm.nih.gov/books/NBK91991/ PubMed PMID: 22553863.

Fontan L, Yang C, Kabaleeswaran V, Volpon L, Osborne MJ, Beltran E, Garcia M, Cerchietti L, Shaknovich R, Yang SN, Fang F, Gascoyne RD, Martinez-Climent JA, Glickman JF, Borden K, Wu H, Melnick A. (2012) MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell. Dec 11;22(6):812-24. doi: 10.1016/j.ccr.2012.11.003. PubMed PMID: 23238016.

Gold B, Pingle M, Brickner SJ, Shah N, Roberts J, Rundell M, Bracken WC, Warrier T, Somersan S, Venugopal A, Darby C, Jiang X, Warren JD, Fernandez J, Ouerfelli O, Nuermberger EL, Cunningham-Bussel A, Rath P, Chidawanyika T, Deng H, Realubit R, Glickman JF, Nathan CF. (2012) Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials.Proc Natl Acad Sci U S A.  Oct 2;109(40):16004-11. doi: 10.1073/pnas.1214188109. Epub 2012 Sep 10. PubMed PMID: 23012453.

Talekar A, Pessi A, Glickman F, Sengupta U, Briese T, et al. (2012) Rapid Screening for Entry Inhibitors of Highly Pathogenic Viruses under Low-Level Biocontainment. PLoS ONE 7(3): e30538. doi:10.1371/journal.pone.0030538

Kawashima SA, Takemoto A, Nurse P, Kapoor TM. Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology. (2012) Chem Biol. Jul 27;19(7):893-901. doi:10.1016/j.chembiol.2012.06.008. PubMed PMID: 22840777; PubMed Central PMCID: PMC3589755.

Ng WL, Perez L, Cong J, Semmelhack MF, Bassler BL. Broad spectrumpro-quorum-sensing molecules as inhibitors of virulence in vibrios. PLoS Pathog. 2012;8(6):e1002767. doi: 10.1371/journal.ppat.1002767. Epub 2012 Jun 28. PubMed PMID: 22761573; PubMed Central PMCID: PMC3386246.

Negri, A., Li, J., Naini, S., Coller, B. S., & Filizola, M. (2012). Structure-based virtual screening of small molecule antagonists of platelet integrin αIIbβ3 that do not prime the receptor to bind ligand. Journal of computer-aided molecular design, 26(9), 1005-1015.

Twomey, E. C., & Wei, Y. (2012). High-definition NMR structure of PED/PEA-15 death effector domain reveals details of key polar side chain interactions.Biochemical and Biophysical Research Communications, 424(1), 141-146.

Twomey, E. C., Cordasco, D. F., & Wei, Y. (2012). Profound conformational changes of PED/PEA-15 in ERK2 complex revealed by NMR backbone dynamics. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics.

Mazloum N, Stegman MA, Croteau DL, Van Houten B, Kwon NS, Ling Y, Dickinson C,Venugopal A, Towheed MA, Nathan C. Identification of a chemical that inhibits the mycobacterial UvrABC complex in nucleotide excision repair. (2011) Biochemistry.Mar 1;50(8):1329-35. doi: 10.1021/bi101674c. Epub 2011 Jan 31. PubMed PMID: 21235228; PubMed Central PMCID: PMC3042777.

Rusinova R, Herold KF, Sanford RL, Greathouse DV, Hemmings HC Jr, Andersen OS. Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery. J Gen Physiol. 2011 Aug;138(2):249-70. doi: 10.1085/jgp.201010529. PubMed PMID: 21788612; PubMed Central PMCID: PMC3149818.

Pipalia, N.H., Cosner, C.C., Huang, A, Chatterjee, A., Bourbon, P., Farley, N., Helquist, P., Wiest, O., and Maxfield, F.R. (2011) Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick Type C1 mutant human fibroblasts. Proc. Natl. Acad. Sci., USA, 108: 5620-5625.

Smirnova NA, Haskew-Layton RE, Basso M, Hushpulian DM, Payappilly JB, Speer RE, Ahn YH, Rakhman I, Cole PA, Pinto JT, Ratan RR, Gazaryan IG. Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators.(2011) Chem Biol. Jun 24;18(6):752-65.doi: 10.1016/j.chembiol.2011.03.013. PubMed PMID: 21700211; PubMed Central PMCID:PMC3251032.

Rujoi, M., Pipalia, N.H., and Maxfield, F.R. (2010) Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells. PLoSONE 5: e12788. doi:10.1371/journal.pone.0012788.

Ahn HJ, Zamolodchikov D, Cortes-Canteli M, Norris EH, Glickman JF, Strickland S. Alzheimer's disease peptide beta-amyloid interacts with fibrinogen and induces its oligomerization. (2010) Proc Natl Acad Sci U S A. Dec 14;107(50):21812-7.  Nov 22. PubMed PMID: 21098282; PubMed Central PMCID: PMC3003082.

VanderVen, B.C., Hermetter, A., Huang, A., Maxfield, F.R., Russell, D.G., and Yates, R.M. (2010), Development of a novel cell-based chemical screen to identify novel inhibitors of intraphagosomal lipolysis in macrophages. Cytometry part A 77: 751-760.

Smirnova NA, Rakhman I, Moroz N, Basso M, Payappilly J, Kazakov S, Hernandez-Guzman F, Gaisina IN, Kozikowski AP, Ratan RR, Gazaryan IG. (2010) Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation. Chem Biol.Apr 23;17(4):380-91. PMID: 20416509.

Rosenbaum, A.I., Rujoi, M., Huang, A.Y., Du, H., Grabowski, G.A., and Maxfield, F.R. (2009) Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors. BBA - Molecular and Cell Biology of Lipids 1791:1155-1165

Lin, G., Li, D. Sorio de Carvalho, L. P.; Deng, H., Tao, H., Vogt, G.,Wu, K., Schneider, J.; Chidawanyika, T.; Warren, J. D., Li, H., Nathan, C. (2009) Inhibitors Selective for Mycobacterial versus Human Proteasomes. Nature, DOI: 10.1038/nature08357

Porotto M, Orefice G, Yokoyama CC, Mungall BA, Realubit R, Sganga ML, Aljofan M, Whitt M, Glickman F, Moscona A. (2009) Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy J Virol.;83(10):5148-55

Glickman, J. F. (2009) Assay Development for Protein Kinases and Phosphatases. In A Practical guide to Assay Development for High Throughput Screening Taosheng Chen, ed., Taylor and Francis Publishers, London.

Blue R, Murcia M, Karan C, Jirousková M, Coller BS. Application of high-throughput screening to identify a novel alphaIIb-specific small- molecule inhibitor of alphaIIbbeta3-mediated platelet interaction with fibrinogen. (2008) Blood. Feb 1;111(3):1248-56

Georgescu RE, Yurieva O, Kim SS, Kuriyan J, Kong XP, O'Donnell M. (2008) Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp. Proc Natl Acad Sci U S A. Aug 12;105(32):11116-21. doi: 10.1073/pnas.0804754105. Epub 2008 Aug 4. PubMed PMID: 18678908; PubMed Central PMCID: PMC2495014.

Farrell, J., Ramos, L., Tresguerres, M., Kamenetsky, M., Levin, L.R., and Buck, J. (2008). Somatic 'Soluble' adenylyl cyclase isoforms are unaffected in Sacytm1Lex/Sacytm1Lex 'Knockout' mice. PLoS ONE 3(9) e3251.

Ramos, L., Zippin, J.H., Kamenetsky, M., Buck, J., and Levin, L.R. (2008). Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. J. Gen. Physiol. 132: 329-338.

Kang Y, Taldone T, Clement CC, Fewell SW, Aguirre J, Brodsky JL, Chiosis G. (2008) Design of a fluorescence polarization assay platform for the study of human Hsp70. Bioorg Med Chem Lett. Jul 1;18(13):3749-

Kenneth D. Bromberg, Avi Ma'ayan, Susana R. Neves, Ravi Iyengar(2008) Design Logic of a Cannabinoid Receptor Signaling Network That Triggers Neurite Outgrowth. Science 320, 903

Peters U, Cherian J, Kim JH, Kwok BH, Kapoor TM. (2006) Probing cell-division phenotype space and Polo-like kinase function using small molecules Nat Chem Biol. Nov;2(11):618-26.

Pipalia NH, Huang A, Ralph H, Rujoi M, Maxfield FR (2006) Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells. J Lipid Res. Feb;47(2):284-301

Wu, K.Y., Zippin, J.H., Huron, D.R., Kamenetsky, M., Hengst, U., Buck, J., Levin, L.R., and Jaffrey, S.R. (2006). Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Nature Neuroscience. 9: 1257-1264.

Moulick K, Clement CC, Aguirre J, Kim J, Kang Y, Felts S, Chiosis G. Synthesis of a red-shifted fluorescence polarization probe for Hsp90. Bioorg. (2006) Med. Chem. Lett., (16):4515-4518.

Janjusevic, R., Abramovitch, R. B., Martin, G. B., & Stebbins, C. E. (2006). A bacterial inhibitor of host programmed cell death defenses is an E3 ubiquitin ligase. Science, 311(5758), 222-226.

Hess, K.C., Jones, B.H., Marquez, B., Chen, Y., Ord, T.S., Kamenetsky, M., Myamoto, C., Zippin, J.H., Kopf, G.S., Suarez, S.S., Levin, L.R., Williams, C.J., Buck, J., and Moss, S.B. (2005). 'Soluble' Adenylyl Cyclase mediates Multiple Specific Signaling Events in Sperm Required for Fertilization. Dev. Cell 9: 249-259.

Han, H., Stessin, A.M., Roberts, J., Hess, K.C., Gautam, N., Kamenetsky, M., Lou, O., Hyde, E., Nathan, N., Muller, W.A., Buck, J., Levin, L.R., and Nathan, C. (2005). Role of Calcium-Sensing Soluble Adenylyl Cyclase in TNF Signal Transduction in Human Neutrophils. J. Exp. Med. 202: 353-361.

Hotha S, Yarrow JC, Yang JG, Garrett S, Renduchintala KV, Mayer TU, Kapoor TM. (2003) HR22C16: a potent small-molecule probe for the dynamics of cell division Angew Chem Int Ed Engl.May 30;42(21):2379-82