Hilda Amalia Pasolli, Ph.D.Research Associate Professor
Mammalian Cell Biology and Development
Using electron microscopy and other techniques, Dr. Pasolli studies how stem cells located within the skin give rise to the skin’s top layer, the epidermis, and to skin appendages such as hair follicles and sebaceous glands. By using a broad repertoire of ultrastructural approaches to visualize normal and aberrant skin cell structures after key signaling molecules in the skin have been deleted or disrupted, Dr. Pasolli's research has led to several important insights on how skin cells proliferate, differentiate and regenerate. Elucidating the normal process of tissue development is an important first step in understanding how these processes go awry in genetic skin diseases, including cancers.
Working closely with Elaine Fuchs, Dr. Pasolli has helped uncover GATA-3 as a gene that underlies the development of several layers of the hair follicle, including the inner root sheath, which shapes and guides the hair through the skin. Dr. Pasolli has also contributed to showing how microRNAs affect skin development.
Dr. Pasolli received her Ph.D. in chemical sciences from the Cordoba National University in Argentina in 1993. She conducted postdoctoral research in the department of neurobiology at Heidelberg University in Germany from 1994 until 1998. She then returned to Cordoba as assistant professor and researcher at the Center for Electron Microscopy. She joined the Fuchs lab at Rockefeller as a research assistant professor in 2002 and was promoted to research associate professor in 2008. Dr. Pasolli was the recipient of the Diatome Award for her work on electron microscopy of skin in 2005.