Alexander Rudensky, Ph.D.Tri-Institutional Professor
Investigator, Howard Hughes Medical Institute
Memorial Sloan-Kettering Cancer Center
Program in Immunology
Dr. Rudensky’s research is focused on understanding how T cells develop and their role in immunity and tolerance. Major areas of interest in his laboratory include: the molecular and cellular mechanisms governing the differentiation and function of CD4 T lymphocytes; the roles these cells play in controlling autoimmunity, tumor immunity and immunity to infections; and the maintenance of immune homeostasis at environmental interfaces.
Dr. Rudensky is particularly interested in understanding the role of the forkhead family transcription factor Foxp3 in establishing and maintaining immune homeostasis; in the plasticity of regulatory T cell transcriptional and functional programs; and in the molecular mechanisms of regulatory T cell lineage stability. In these studies, the Rudensky laboratory employs a wide range of experimental techniques including traditional biochemical and molecular biological analyses; genetic approaches including conventional and conditional gene targeting and transgenesis; mass spectrometry; large-scale gene expression analyses and bioinformatics; and classical immunological analyses utilizing both cellular in vitro techniques and whole animal experimentation.
- Zheng, Y. et al. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 463, 808–812 (2010).
- Chaudhry, A. et al. CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science 326, 986–991 (2009).
- Lund, J.M. et al. Coordination of early protective immunity to viral infection by regulatory T cells. Science 320, 1220–1224 (2008).