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RU 359: Choi, et al. Identification Of TRIP, A Novel Protein That Inhibits NF-κb Activation.
RU 360: O'Donnell, et al. Human origin of replication complex genes and uses thereof.
This patent describes the DNA and protein sequences of human origin of recognition complex subunits 4 and 5 and their use in identifying lead compounds for the diagnosis and treatment of disease associated with cell growth.
RU 383: Dean, et al. DNA molecules encoding single strand gap response proteins involved in activation of a DNA repair/cell cycle checkpoint pathway.
This invention describes the DNA sequences of mammalian, including human single strand gap response (SSGR) proteins involved in activation of a DNA repair/cell cycle checkpoint pathway, and their diagnostic and therapeutic applications. Transgenic mice that lack functional copies of the genes and are characterized by spontaneous tumor development, are also described.
RU 385: Darnell, et al. A Novel Pathway For The Activation Of Tumor Immune Responses.
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RU 824: Darnell, et al. Novel Agents for the Treatment and Diagnosis of Breast and Ovarian Cancer.
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RU 1034: Steller, et al. Novel Activators of Apoptosis That Are Targeted to the Mitochondrial Membrane.