Cancer

RU 304, 355, 406, 671: de Lange, et al. Vertebrate telomeric proteins involved in cancer and cellular aging.

RU 359: Choi, et al. Identification Of TRIP, A Novel Protein That Inhibits NF-κb Activation.

RU 360: O'Donnell, et al. Human origin of replication complex genes and uses thereof.
This patent describes the DNA and protein sequences of human origin of recognition complex subunits 4 and 5 and their use in identifying lead compounds for the diagnosis and treatment of disease associated with cell growth.

RU 383: Dean, et al. DNA molecules encoding single strand gap response proteins involved in activation of a DNA repair/cell cycle checkpoint pathway.
This invention describes the DNA sequences of mammalian, including human single strand gap response (SSGR) proteins involved in activation of a DNA repair/cell cycle checkpoint pathway, and their diagnostic and therapeutic applications. Transgenic mice that lack functional copies of the genes and are characterized by spontaneous tumor development, are also described.

RU 385: Darnell, et al. A Novel Pathway For The Activation Of Tumor Immune Responses.

RU 420: Ho, et al. A Novel and Quantitative Diagnostic Assay for Nucleic Acid-Based Markers.

RU 431: Darnell, et al. A New Family of Transcription Factors Involved in Oncogenesis.

RU 594: Steller, et al. Modulators of Apoptotic Cell Death.

RU 824: Darnell, et al. Novel Agents for the Treatment and Diagnosis of Breast and Ovarian Cancer.

RU 963: Simon, et al. Novel Use of Auto-Antibodies for Early Detection and Treatment of Cancer.

RU 999: Ravetch, et al. Modified Anti-CD40 Antibodies for Improved Treatment of Tumors.

RU 1034: Steller, et al. Novel Activators of Apoptosis That Are Targeted to the Mitochondrial Membrane.

RU 1101: Allis, et al. Novel Peptide Inhibitors of PRC2 for the Treatment of Cancer.