Tangible Materials

Monoclonal Antibodies: MAbs

Fuchs, et al. Available mouse strains.

Heintz, et al. Characterized BAC transgenic mice lines.

RU 304, 355, 406, 671: de Lange, et al. Vertebrate telomeric proteins involved in cancer and cellular aging.

RU 550: Friedman, et al. Bac transgenic mice with Green Fluorescent Protein (GFP) labelled neurons.
For a description please refer to: Liu, et al. Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J NEUROSCI 2003 AUG 6;23(18):7143-7154.

  1. MCH-GFP - Bac transgenic mice in which all MCH-GFP neurons are labelled with GFP
  2. MC4R- GFP - Bac transgenic mice in which all MCR4-GFP neurons are labelled with GFP
  3. POMC-GFP - Bac transgenic mice in which all POMC-GFP neurons are labelled with GFP
  4. NPY-GFP - Bac transgenic mice in which all NPY-GFP neurons are labelled with GFP

RU 602: Nussenzweig, et al. Mannose Receptor knockout mice.
For a description please access: http://www.sciencemag.org/cgi/content/full/295/5561/1898/DC1.

RU 657: Friedman, et al. GPR7 knockout mice.
For a detailed description please refer to: Ishii M, Fei H, Friedman JM Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult- onset obesity. PROC NAT ACAD SCI USA 2003 SEP 2;100(18):10540-10545

RU 663: Friedman, et al. TRPV4 knockout mouse line, TRPV4 stable cell line and TRPV4full-length cDNA mice.
For a detailed description please refer to: Liedtke W, Friedman JM Abnormal osmotic regulation in trpv4(-/-) mice. PROC NAT ACAD SCI USA 2003 NOV 11;100(23):13698-13703

RU 609: Chait, et al. A peptide useful for antibody or Protein A (PrA)-tagged protein purification.
This peptide effectively competes with the interaction between IgG and PrA. It can be used to purify IgG antibodies, PrA-tagged proteins, and PrA-tagged protein complexes. As this method does not involve denaturation, the use of this peptide maintains protein complex formation and native structure.

RU 709: Steller, et al. Sept4 null mice to study the function of Sept4 proteins in vivo and terminal sperm differentiation.
For a full description, see Kissel, et al., 2005. The Sept4 septin locus is required for sperm terminal differentiation in mice. Dev. Cell, 8:353-364.

RU 783: Greengard, et al. p11 knockout mouse model for depression.
This is a genetically engineered mouse that can be used to screen for potential therapeutic agents for the treatment of depression. These mice have a decreased response to anti-depressants. For a detailed description, please refer to: Svenningson, et al. Science, 311:77-80 (2006).

Research Tools

RU 499: Simon, et al. Generation of specific and detectable primary antibodies.

RU 535: Wittkowski, et al. A Novel Multivariate Statistical Approach to Assess Efficacy and Risk of Side Effects in Clinical Trials and Personalized Medicine.

RU 621, 624, 625, 637, 651, 654, 755, 764, 885: Fischetti, et al. Lysins: Novel Proteins to Diagnose and Treat Gram-Positive Bacterial Infections.

RU 621, 624, 625, 637, 651, 654, 755, 764, 885: Fischetti, et al. Biological Decontamination of Bacterial Pathogens.

RU 621, 624, 625, 637, 651, 654, 755, 764, 885: Fischetti, et al. Novel Enzymes for Efficient Nucleic Acid Extraction.

RU 648, 864, 927, 902: Darnell, et al. CLIP and HITS-CLIP: Novel Techniques to Identify RNA Targets of RNA-Binding Proteins and Ribonucleoprotein Complexes.

RU 648, 864, 927: Darnell, et al. A Novel Method for Identification of Targets for RNA-Binding Proteins.

RU 666: Muesing, et al. Nuclear Delivery of Biomolecules using Lentiviral Integrase.

RU 681, 697, 732, 749: Tuschl, et al. Human and Viral MicroRNA Molecules and Inhibition of Their RNA Interference (RNAi) Activity.

RU 830: Tuschl, et al. A Novel Ligase-Based System to Efficiently Label MicroRNAs.

RU 848: Steinman, et al. A Novel Epitope Tag and Highly Sensitive Monoclonal Antibodies for Improved Immunodetection of Tagged Proteins.

RU 867: Leibler, et al. An Inexpensive Portable Holographic Microscopic Device.

RU 870: Sakmar, et al. A Novel Method for the Production of Nanoscale Membrane Particles.

RU 878: Brivanlou, et al. ePiggyBac: A Novel Tool For Reprogramming Human Cells.

RU 902: Tuschl, et al. A Novel Technique to Identify RNA Targets of RNA-Binding Proteins and Ribonucleoprotein Complexes.

RU 910, 1030: Tuschl, et al. A Novel Method For MicroRNA, Non-coding RNA and mRNA Detection By In-situ Hybridization.

RU 962: Papavasiliou, et al. Novel Engineered Trypanosomes as Vaccine Delivery Vectors.