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Cohen YZ

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Safety, pharmacokinetics, and immunogenicity of the combination of the

PLOS ONE 2019 AUG 8; 14(8):? Article e0219142

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Background

Liu K

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PI31 Is an Adaptor Protein for Proteasome Transport in Axons and

DEVELOPMENTAL CELL 2019 AUG 19; 50(4):509-524.e10

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Protein degradation by the ubiquitin-proteasome system is critical for

Esteghamat F

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CELA2A mutations predispose to early-onset atherosclerosis and metabolic

NATURE GENETICS 2019 AUG; 51(8):1233-1243

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Factors that underlie the clustering of metabolic syndrome traits are

Libis V

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Uncovering the biosynthetic potential of rare metagenomic DNA using

NATURE COMMUNICATIONS 2019 AUG 26; 10(?):? Article 3848

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Sequencing of DNA extracted from environmental samples can provide key

Khourieh J

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A deep intronic splice mutation of STAT3 underlies hyper IgE syndrome by

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF 2019 AUG 13; 116(33):16463-16472

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Heterozygous in-frame mutations in coding regions of human STAT3

Frank I

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A Tat/Rev Induced Limiting Dilution Assay to Measure Viral Reservoirs in

SCIENTIFIC REPORTS 2019 AUG 19; 9(?):? Article 12078

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The establishment of latent infection and poorly characterized viral

Zhang SY, Jouanguy E, Zhang Q, Abel L, Puel A, Casanova JL

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Human inborn errors of immunity to infection affecting cells other than leukocytes: from the immune system to the whole organism

CURRENT OPINION IN IMMUNOLOGY 2019 AUG; 59(?):88-100

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Studies of vertebrate immunity have traditionally focused on professional cells, including circulating and tissue-resident leukocytes. Evidence that non-professional cells are also intrinsically essential (i.e. not via their effect on leukocytes) for protective immunity in natural conditions of infection has emerged from three lines of research in human genetics. First, studies of Mendelian resistance to infection have revealed an essential role of DARC-expressing erythrocytes in protection against Plasmodium vivax infection, and an essential role of FUT2-expressing intestinal epithelial cells for protection against norovirus and rotavirus infections. Second, studies of inborn errors of non-hematopoietic cell-extrinsic immunity have shown that APOL1 and complement cascade components secreted by hepatocytes are essential for protective immunity to trypanosome and pyogenic bacteria, respectively. Third, studies of inborn errors of non-hematopoietic cell-intrinsic immunity have suggested that keratinocytes, pulmonary epithelial cells, and cortical neurons are essential for tissue-specific protective immunity to human papillomaviruses, influenza virus, and herpes simplex virus, respectively. Various other types of genetic resistance or predisposition to infection in human populations are not readily explained by inborn variants of genes operating in leukocytes and may, therefore, involve defects in other cells. The probing of this unchartered territory by human genetics is reshaping immunology, by scaling immunity to infection up from the immune system to the whole organism.

Galea S, Vaughan R

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On Choosing the Right Starting Question: A Public Health of Consequence, August 2019

AMERICAN JOURNAL OF PUBLIC HEALTH 2019 AUG; 109(8):1075-1076

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Munoz E

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Canal shaping with a reciprocating system is easy to learn

INTERNATIONAL ENDODONTIC JOURNAL 2019 AUG; 52(8):1244-1249

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Aim To assess progressive learning of root canal shaping in order to

Witt E

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Testis single-cell RNA-seq reveals the dynamics of de novo gene

ELIFE 2019 AUG 16; 8(?):? Article e47138

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The testis is a peculiar tissue in many respects. It shows patterns of