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Dunn AD
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Signaling Properties of Structurally Diverse Kappa Opioid Receptor

ACS CHEMICAL NEUROSCIENCE 2019 AUG; 10(8):3590-3600
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Biased ligands preferentially activate certain signaling pathways
Hertz NT
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Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon

NEURON 2019 AUG 7; 103(3):412-422.e4
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Selective synaptic and axonal degeneration are critical aspects of both
Roco JA
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Class-Switch Recombination Occurs Infrequently in Germinal Centers

IMMUNITY 2019 AUG 20; 51(2):337-350.e7
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Class-switch recombination (CSR) is a DNA recombination process that
Sabri A
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Prevalence and risk factors for latent tuberculosis infection among

PLOS ONE 2019 AUG 15; 14(8):? Article e0221081
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Increased prevalence of latent tuberculosis infection (LTBI) has been
Blackmon K
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Cortical gray-white matter blurring and declarative memory impairment in

EPILEPSY & BEHAVIOR 2019 AUG; 97(?):34-43
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Magnetic resonance imaging (MRI)- negative temporal lobe epilepsy (TLE)
Belkaya S
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Inherited IL-18BP deficiency in human fulminant viral hepatitis

JOURNAL OF EXPERIMENTAL MEDICINE 2019 AUG; 216(8):1777-1790
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Fulminant viral hepatitis (FVH) is a devastating and unexplained
Huang YC
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Gain-of-function mutations in the UNC-2/CaV2 alpha channel lead to

ELIFE 2019 AUG 5; 8(?):? Article e45905
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Mutations in pre-synaptic voltage-gated calcium channels can lead to
Lopez-Hernandez I
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Skewed X-inactivation in a Female Carrier with X-linked Chronic

IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY 2019 AUG; 18(4):447-451
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Chronic granulomatous disease (CGD) is a primary immunodeficiency caused
Brunner PM, He H, Pavel AB, Czarnowicki T, Lefferdink R, Erickson T, Canter T, Puar N, Rangel SM, Malik K, Estrada Y, Krueger JG, Guttman-Yassky E, Paller AS
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The blood proteomic signature of early-onset pediatric atopic dermatitis shows systemic inflammation and is distinct from adult long-standing disease

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 2019 AUG; 81(2):510-519
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Background: Despite increasing evidence that adults with long-standing atopic dermatitis (AD) have systemic inflammation, little is known about systemic inflammation in recent-onset early pediatric AD. Objective: To analyze blood inflammatory proteins of early pediatric AD. Methods: Using high-throughput proteomics (proximity extension assay), we assessed 257 inflammatory and cardiovascular risk proteins in the blood of 30 children with moderate to severe AD younger than 5 years of age (within 6 months of onset) compared with age-matched pediatric control individuals and adult patients with AD. Results: In pediatric AD blood, T helper (Th) type 2 (CCL13, CCL22) and Th17 (peptidase inhibitor-3/elafin) markers were increased, together with markers of tissue remodeling (matrix metalloproteinases 3/9/10, urokinase receptor), endothelial activation (E-selectin), T-cell activation (IL2RA), neutrophil activation (myeloperoxidase), lipid metabolism (FABP4), and growth factors (FGF21, transforming growth factor-alpha). Total numbers of dysregulated proteins were smaller in pediatric AD (n = 22) than in adult AD (n = 61). Clinical severity scores were positively correlated with receptors for interleukins 33 and 36 and inversely correlated with some Th1 markers (interferon gamma, CXCL11). Limitations: Different baseline expression levels in healthy pediatric vs adult samples. Conclusions: Within months of pediatric AD onset, systemic immune activation is present, with Th2/Th17 skewing but otherwise different proteomic patterns from adult AD. Future correlation of proteomic patterns with disease course, comorbidity development, and drug response may yield predictive biomarkers.
Frew JW
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Assessing the efficacy of new biologic therapies in hidradenitis

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 2019 AUG; 33(8):E298-E300
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Linked article: M. Kovacs et al. J Eur Acad Dermatol Venereol 2019; 33:
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