The rockefeller university

2024

Cellular ATP demand creates metabolically distinct subpopulations of mitochondria.

Ryu KW, Fung TS, Baker DC, Saoi M, Park J, Febres-Aldana CA, Aly RG, Cui R, Sharma A, Fu Y, Jones OL, Cai X, Pasolli HA, Cross JR, Rudin CM, Thompson CB.

Nature. 2024 Nov 6. doi: 10.1038/s41586-024-08146-w. Online ahead of print.PMID: 39506109

Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration.

Lyu Y, Kim SJ, Humphrey ES, Nayak R, Guan Y, Liang Q, Kim KH, Tan Y, Dou J, Sun H, Song X, Nagarajan P, Gerner-Mauro KN, Jin K, Liu V, Hassan RH, Johnson ML, Deliu LP, You Y, Sharma A, Pasolli HA, Lu Y, Zhang J, Mohanty V, Chen K, Yang YJ, Chen T, Ge Y.

Cell. 2024 Oct 23:S0092-8674(24)01155-3. doi: 10.1016/j.cell.2024.10.007. Online ahead of print.PMID: 39476839

Stem cells tightly regulate dead cell clearance to maintain tissue fitness. 

Stewart KS, Abdusselamoglu MD, Tierney MT, Gola A, Hur YH, Gonzales KAU, Yuan S, Bonny AR, Yang Y, Infarinato NR, Cowley CJ, Levorse JM, Pasolli HA, Ghosh S, Rothlin CV, Fuchs E.

Nature. 2024 Aug 21. doi: 10.1038/s41586-024-07855-6. Online ahead of print. PMID: 39169186

Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties. 

Hanzel M, Fernando K, Maloney SE, Horn Z, Gong S, Mätlik K, Zhao J, Pasolli HA, Heissel S, Dougherty JD, Hull C, Hatten ME.

Proc Natl Acad Sci U S A. 2024 Aug 20;121(34):e2405901121. doi: 10.1073/pnas.2405901121. Epub 2024 Aug 16. PMID: 39150780 Free PMC article.

Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells. 

Winer BY, Settle AH, Yakimov AM, Jeronimo C, Lazarov T, Tipping M, Saoi M, Sawh A, Sepp AL, Galiano M, Perry JSA, Wong YY, Geissmann F, Cross J, Zhou T, Kam LC, Pasolli HA, Hohl T, Cyster JG, Weiner OD, Huse M.

Sci Immunol. 2024 Jun 7;9(96):eadl2388. doi: 10.1126/sciimmunol.adl2388. Epub 2024 Jun 7. PMID: 38848343

Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation. 

Xin T, Gallini S, Wei H, Gonzalez DG, Matte-Martone C, Machida H, Fujiwara H, Pasolli HA, Suozzi KC, Gonzalez LE, Regot S, Greco V.

Nat Cell Biol. 2024 Jun;26(6):859-867. doi: 10.1038/s41556-024-01413-y. Epub 2024 Apr 30. PMID: 38689013

CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment. 

Luan J, Truong C, Vuchkovska A, Guo W, Good J, Liu B, Gang A, Infarinato N, Stewart K, Polak L, Pasolli HA, Andretta E, Rudensky AY,
Fuchs E, Miao Y.

Immunity. 2024 May 14;57(5):1071-1086.e7. doi: 10.1016/j.immuni.2024.04.003. Epub 2024 Apr 26. PMID: 38677291

Lecanemab blocks the effects of the Aβ/fibrinogen complex on blood clots and synapse toxicity in organotypic culture. 

Singh PK, Simões-Pires EN, Chen ZL, Torrente D, Calvano M, Sharma A, Strickland S, Norris EH.

Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2314450121. doi: 10.1073/pnas.2314450121. Epub 2024 Apr 15. PMID: 38621133 Free PMC article.

Motion of VAPB molecules reveals ER-mitochondria contact site subdomains. 

Obara CJ, Nixon-Abell J, Moore AS, Riccio F, Hoffman DP, Shtengel G, Xu CS, Schaefer K, Pasolli HA, Masson JB, Hess HF, Calderon CP, Blackstone C, Lippincott-Schwartz J.

Nature. 2024 Feb;626(7997):169-176. doi: 10.1038/s41586-023-06956-y. Epub 2024 Jan 24. PMID: 38267577 Free PMC article.

An mTurq2-Col4a1 mouse model allows for live visualization of mammalian basement membrane development. 

Jones RA, Trejo B, Sil P, Little KA, Pasolli HA, Joyce B, Posfai E, Devenport D.

J Cell Biol. 2024 Feb 5;223(2):e202309074. doi: 10.1083/jcb.202309074. Epub 2023 Dec 5. PMID: 38051393 Free PMC article.

2023

Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome. 

Venkatraman K, Lee CT, Garcia GC, Mahapatra A, Milshteyn D, Perkins G, Kim KY, Pasolli HA, Phan S, Lippincott-Schwartz J, Ellisman MH, Rangamani P, Budin I.

EMBO J. 2023 Dec 11;42(24):e114054. doi: 10.15252/embj.2023114054. Epub 2023 Nov 7. PMID: 37933600 Free PMC article.

Morphogens enable interacting supracellular phases that generate organ architecture. 

Yang S, Palmquist KH, Nathan L, Pfeifer CR, Schultheiss PJ, Sharma A, Kam LC, Miller PW, Shyer AE, Rodrigues AR.

Science. 2023 Nov 24;382(6673):eadg5579. doi: 10.1126/science.adg5579. Epub 2023 Nov 24. PMID: 37995219

Organ function is preserved despite reorganization of niche architecture in the hair follicle. 

Wei H, Du S, Parksong J, Pasolli HA, Matte-Martone C, Regot S, Gonzalez LE, Xin T, Greco V.

Cell Stem Cell. 2023 Jul 6;30(7):962-972.e6. doi: 10.1016/j.stem.2023.06.003. PMID: 37419106 Free PMC article.

Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals. 

Kenny TC, Khan A, Son Y, Yue L, Heissel S, Sharma A, Pasolli HA, Liu Y, Gamazon ER, Alwaseem H, Hite RK, Birsoy K.

Cell Metab. 2023 Jun 6;35(6):1057-1071.e12. doi: 10.1016/j.cmet.2023.04.003. Epub 2023 Apr 25. PMID: 37100056 Free PMC article.

A tissue injury sensing and repair pathway distinct from host pathogen defense. 

Liu S, Hur YH, Cai X, Cong Q, Yang Y, Xu C, Bilate AM, Gonzales KAU, Parigi SM, Cowley CJ, Hurwitz B, Luo JD, Tseng T, Gur-Cohen S, Sribour M, Omelchenko T, Levorse J, Pasolli HA, Thompson CB, Mucida D, Fuchs E.

Cell. 2023 May 11;186(10):2127-2143.e22. doi: 10.1016/j.cell.2023.03.031. Epub 2023 Apr 24. PMID: 37098344 Free PMC article.

Autolysosomal exocytosis of lipids protect neurons from ferroptosis. 

Ralhan I, Chang J, Moulton MJ, Goodman LD, Lee NYJ, Plummer G, Pasolli HA, Matthies D, Bellen HJ, Ioannou MS.

J Cell Biol. 2023 Jun 5;222(6):e202207130. doi: 10.1083/jcb.202207130. Epub 2023 Apr 10. PMID: 37036445 Free PMC article.

A general method for quantitative fractionation of mammalian cells. 

Udi Y, Zhang W, Stein ME, Ricardo-Lax I, Pasolli HA, Chait BT, Rout MP.

J Cell Biol. 2023 Jun 5;222(6):e202209062. doi: 10.1083/jcb.202209062. Epub 2023 Mar 15. PMID: 36920247 Free PMC article.

2022

The pupal moulting fluid has evolved social functions in ants. 

Snir O, Alwaseem H, Heissel S, Sharma A, Valdés-Rodríguez S, Carroll TS, Jiang CS, Razzauti J, Kronauer DJC.

Nature. 2022 Dec;612(7940):488-494. doi: 10.1038/s41586-022-05480-9. Epub 2022 Nov 30. PMID: 36450990 Free PMC article.

Bioinformatic prospecting and synthesis of a bifunctional lipopeptide antibiotic that evades resistance. 

Wang Z, Koirala B, Hernandez Y, Zimmerman M, Brady SF.

Science. 2022 May 27;376(6596):991-996. doi: 10.1126/science.abn4213. Epub 2022 May 26. PMID: 35617397

The integrated stress response remodels the microtubule-organizing center to clear unfolded proteins following proteotoxic stress.

Hurwitz B, Guzzi N, Gola A, Fiore VF, Sendoel A, Nikolova M, Barrows D, Carroll TS, Pasolli HA, Fuchs E.

Elife. 2022 Jun 27;11:e77780. doi: 10.7554/eLife.77780. PMID: 35758650 Free PMC article.

Lymphatics act as a signaling hub to regulate intestinal stem cell activity.

Niec RE, Chu T, Schernthanner M, Gur-Cohen S, Hidalgo L, Pasolli HA, Luckett KA, Wang Z, Bhalla SR, Cambuli F, Kataru RP, Ganesh K, Mehrara BJ, Pe’er D, Fuchs E.

Cell Stem Cell. 2022 Jul 7;29(7):1067-1082.e18. doi: 10.1016/j.stem.2022.05.007. Epub 2022 Jun 20. PMID: 35728595

2021

Stem cells expand potency and alter tissue fitness by accumulating diverse epigenetic memories.

Gonzales KAU, Polak L, Matos I, Tierney MT, Gola A, Wong E, Infarinato NR, Nikolova M, Luo S, Liu S, Novak JSS, Lay K, Pasolli HA, Fuchs E.

Science. 2021 Nov 26;374(6571):eabh2444. doi: 10.1126/science.abh2444. Epub 2021 Nov 26. PMID: 34822296 Free PMC article.

Scanning electron microscopy of murine skin ultrathin sections and cultured keratinocytes.

Banerjee A, Biswas R, Lim R, Pasolli HA, Raghavan S.

STAR Protoc. 2021 Aug 17;2(3):100729. doi: 10.1016/j.xpro.2021.100729. eCollection 2021 Sep 17. PMID: 34458866 Free PMC article.

Uncovering potential interspecies signaling factors in plant-derived mixed microbial culture.

Domzalski A, Perez SD, Yoo B, Velasquez A, Vigo V, Pasolli HA, Oldham AL, Henderson DP, Kawamura A.

Bioorg Med Chem. 2021 Jul 15;42:116254. doi: 10.1016/j.bmc.2021.116254. Epub 2021 Jun 4. PMID: 34119697 Free PMC article.

2020

BMP signaling: at the gate between activated melanocyte stem cells and differentiation.

Infarinato NR, Stewart KS, Yang Y, Gomez NC, Pasolli HA, Hidalgo L, Polak L, Carroll TS, Fuchs E.

Genes Dev. 2020 Dec 1;34(23-24):1713-1734. doi: 10.1101/gad.340281.120. Epub 2020 Nov 12. PMID: 33184221 Free PMC article.

Mechanics of a multilayer epithelium instruct tumour architecture and function.

Fiore VF, Krajnc M, Quiroz FG, Levorse J, Pasolli HA, Shvartsman SY, Fuchs E.

Nature. 2020 Sep;585(7825):433-439. doi: 10.1038/s41586-020-2695-9. Epub 2020 Sep 2. PMID: 32879493 Free PMC article.

m6A RNA methylation impacts fate choices during skin morphogenesis.

Xi L, Carroll T, Matos I, Luo JD, Polak L, Pasolli HA, Jaffrey SR, Fuchs E.

Elife. 2020 Aug 26;9:e56980. doi: 10.7554/eLife.56980. PMID: 32845239 Free PMC article.

Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells.

Shwartz Y, Gonzalez-Celeiro M, Chen CL, Pasolli HA, Sheu SH, Fan SM, Shamsi F, Assaad S, Lin ET, Zhang B, Tsai PC, He M, Tseng YH, Lin SJ, Hsu YC.

Cell. 2020 Aug 6;182(3):578-593.e19. doi: 10.1016/j.cell.2020.06.031. Epub 2020 Jul 16. PMID: 32679029 Free PMC article..

Liquid-liquid phase separation drives skin barrier formation.

Quiroz FG, Fiore VF, Levorse J, Polak L, Wong E, Pasolli HA, Fuchs E.

Science. 2020 Mar 13;367(6483):eaax9554. doi: 10.1126/science.aax9554. PMID: 32165560 Free PMC article.