Mechanistic Studies of Transcriptional Regulation in Hematopoietic Malignancies

Event Details

Type

Monday Lecture Series

Speaker(s)

Robert Roeder, Ph.D., Arnold and Mabel Beckman Professor and head, Laboratory of Biochemistry and Molecular Biology, The Rockefeller University

Speaker bio(s)

The Roeder laboratory is interested in biochemical mechanisms underlying transcriptional regulation by gene- and cell-specific DNA-binding factors in both normal (development, cell differentiation) and pathological (cancer) physiological processes -- and in particular the functions of transcriptional co-activators that include both chromatin modifying factors and other factors (e.g., Mediator and TAFs) that facilitate more direct communication between enhancer-bound regulatory factors and the general transcriptional machinery at the promoter. In the area of hematopoietic malignancies, The Roeder lab has major interests in the mechanism of action of the B cell-specific transcriptional co-activator OCA-B, which is critical for formation of germinal centers and implicated in GCB cell-derived lymphomas, and leukemic fusion proteins that include RUNX1-ETO, E2A-PBX1 and MLL-AF9/ENL. The presentation will describe recent studies that have identified new direct target genes and new mechanisms both for recruitment of these factors to target genes and for downstream effector functions.

Robert G. Roeder received his Ph.D. in biochemistry from the University of Washington in 1969 and did his postdoc at the Carnegie Institution of Washington. He joined the faculty of Washington University School of Medicine in 1971 and came to Rockefeller as a professor in 1982. His numerous awards include a Lewis S. Rosenstiel Award, a Passano Award, a Louisa Gross Horwitz Prize, a Canada Gairdner International Award, an Albert Lasker Basic Medical Research Award, an Albany Medical Center Prize, and a Kyoto Prize. Among other honors, he is a member of the National Academy of Sciences, the American Academy of Arts and Sciences, and an associate member of the European Molecular Biology Organization.

MLS lectures are only open to the RU community and will be taking place in Carson Family Auditorium and virtually via Zoom. Virtual participants are required to log in with their RU Zoom account and use their RU email address and password for authentication. We recommend signing out of VPN prior to logging in to the lecture. Please do not share the link or post on social media.

Open to

Campus Only