The rockefeller university

Event Details

Type

Chemical & Structural Biology Seminar Series

Speaker(s)

Chaitan Khosla, Ph.D., Wells H. Rauser and Harold M. Petiprin Professor and Professor of Chemistry and, by courtesy, of Biochemistry, Department of Chemical Engineering, Stanford University

Speaker bio(s)

Abstract: Celiac disease is a lifelong, inheritable T cell-driven disorder that is triggered by gluten, a ubiquitous and nutritionally important protein source in the human diet. The Khosla lab's investigations into the mechanisms of gluten antigen presentation have led to the identification of an unusual pathway for T cell antigen presentation by dendritic cells. Not only does the “TG2/LRP1” pathway appear to be an exceptionally potent process for the immune system to capture foreign antigens, but it can also be harnessed for targeted protein degradation in a cell-selective manner.

Open to

Tri-Institutional