Science 335: 970-3 (February 24, 2012)
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Science 335: 970–973
Control of nonapoptotic developmental cell death in Caenorhabditis elegans by a polyglutamine-repeat protein
Elyse S. Blum, Mary C. Abraham, Satoshi Yoshimura, Yun Lu and Shai Shaham
In Caenorhabditis elegans, programmed death of the linker cell, which leads gonadal elongation, proceeds independently of caspases and apoptotic effectors. To identify genes promoting linker-cell death, we performed a genome-wide RNA interference screen. We show that linker-cell death requires the gene pqn-41, encoding an endogenous polyglutamine-repeat protein.
