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Science 335: 970-3 (February 24, 2012)

Science 335: 970–973
(opens in new window)Control of nonapoptotic developmental cell death in Caenorhabditis elegans by a polyglutamine-repeat protein(opens in new window)
Elyse S. Blum, Mary C. Abraham, Satoshi Yoshimura, Yun Lu and Shai Shaham

(opens in new window)In Caenorhabditis elegans, programmed death of the linker cell, which leads gonadal elongation, proceeds independently of caspases and apoptotic effectors. To identify genes promoting linker-cell death, we performed a genome-wide RNA interference screen. We show that linker-cell death requires the gene pqn-41, encoding an endogenous polyglutamine-repeat protein.