Molecular Genetic Studies of Central Nervous System Vascular Development and Disease
The Joshua Lederberg Distinguished Lecture in Molecular Genetics
Event Details
- Type
- Friday Lecture Series
- Speaker(s)
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Jeremy Nathans, M.D., Ph.D., professor of molecular biology and genetics, professor of neuroscience, Samuel Theobald Professor of Ophthalmology, Johns Hopkins University School of Medicine; investigator, Howard Hughes Medical Institute
- Speaker bio(s)
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During development, the central nervous system (CNS) vasculature acquires a unique set of molecular and cellular properties – collectively referred to as the blood-brain barrier (BBB) – that minimize passive diffusion of molecules between the blood and the CNS parenchyma. An analogous system in the retina is referred to as the blood-retina barrier. This lecture will describe some of the experiments that serve as the foundation for our current understanding of CNS vascular development and maintenance, and the connections between this work and human disease.
Jeremy Nathans received his undergraduate education at M.I.T., obtained M.D. and Ph.D. degrees from the Stanford University School of Medicine, and conducted post-doctoral research at Genentech. He is a trustee of The Rockefeller University and currently serves as the chair of the Committee on Scientific Affairs (COSA). Over the past 35 years, the Nathans Laboratory has focused on the intersection of human genetics, ophthalmology, retinal cell biology, developmental neuroscience, and evolution. The lab’s current focus is on vascular biology, with a special emphasis on the blood-brain barrier and the blood-retina barrier.
- Open to
- Tri-Institutional