Decision Making during Protein Biogenesis: on the Ribosome and Beyond
Event Details
- Type
- Chemical & Structural Biology Seminar Series
- Speaker(s)
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Shu-ou Shan, Ph.D., Altair Professor of Chemistry and Executive Officer for Biochemistry and Molecular Biophysics, California Institute of Technology
- Speaker bio(s)
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Abstract: Proper protein biogenesis is a pre-requisite for the generation and maintenance of a functional proteome. Accumulating data show that this process begins early, when nascent proteins emerge from the ribosome. Within seconds, the nascent polypeptide must engage the correct set of biogenesis factors and commit to the proper biogenesis pathway. These early decisions profoundly influence the folding, assembly, localization, maturation, and quality control of nascent proteins. How are nascent proteins selected and triaged as they emerge from the ribosome? How does the cellular chaperone network handle aggregation-prone membrane/organellar proteins during their biogenesis? Dr. Shan’s lab aims to address these fundamental questions at biochemical and biophysical resolution, by integrating quantitative approaches in biochemistry, biophysics and mechanistic enzymology with structural and molecular cell biology. In this talk, Dr. Shan will describe recent work that begin to elucidate how diverse protein biogenesis machinery coordinate in space and time at the ribosome to ensure the efficiency and fidelity of individual protein biogenesis pathways, and the discovery of novel molecular chaperones that repair protein misfolding.
- Open to
- Tri-Institutional