Robustness of Morphogenesis via Mechanical Feedbacks
Event Details
- Type
- Center for Studies in Physics and Biology Seminars
- Speaker(s)
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Edouard Hannezo, Ph.D., professor, Institute of Science and Technology Austria (ISTA)
- Speaker bio(s)
-
A central question in biology is how genetic information is integrated across many length scales to shape and pattern cells, organs and organisms. Theoretical biophysics have proven instrumental in proposing minimal conceptual frameworks to understand the self-organizing potential of living matter, as well as to identify key predictions that can be verified experimentally. However, a key feature of multicellular development is not simply the emergence of increasing complex shapes and form, but the fact that this process is robust and reproducible. In this talk, I will present two recent works from our group on understanding how checkpoints for robustness can emerge from simple mechanical principles. Firstly, in the context of intestinal organoid morphogenesis, we show how mechano-sensitive feedbacks can give rise to mechanical bistability, rendering morphogenesis robust to subsequent mechanical perturbations once it’s completed. Secondly, in the context of early mammalian embryogenesis, we show how mechanical compaction can buffer developmental variability and allow embryos to converge towards robust shapes.
- Open to
- Public
- Phone
- (212) 327-8636
- Sponsor
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Melanie Lee
(212) 327-8636
leem@rockefeller.edu