The rockefeller university

Event Details

Type

Center for Studies in Physics and Biology Seminars

Speaker(s)

Jasna Brujic, Ph.D.(opens in new window), assistant professor, New York University

Speaker bio(s)

How collections of building blocks efficiently organize into structures with high fidelity is a central question in both biology and materials science. Here we show that linear chains of DNA-functionalized colloidal droplets (ABAB...) successfully fold into unique 2d foldamer geometries [1], which in turn bind to form nets that can efficiently wrap into icosahedral shells in 3d using optimized temperature protocols. These colloidal capsids can then be opened and closed using enzymatic dynamics that write, cut, and modify the DNA interactions to assemble, disassemble, and reconfigure these structures. Finding such designable self-assembling systems presents a promising route to functional materials that serve a purpose, such as targeted drug delivery and reactive surfaces.

Open to

Public

Phone

(212) 327-8636(opens in new window)

Sponsor

Melanie Lee
(212) 327-8636(opens in new window)
leem@rockefeller.edu(opens in new window)