Cell 147: 590–602 (October 28, 2011)
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Cell 147: 590–602
Molecular Architecture of the Transport Channel of the Nuclear Pore Complex
Sozanne R. Solmaz, Radha Chauhan, Günter Blobel and Ivo Melčák
The nuclear pore complex encloses a central channel for nucleocytoplasmic transport, which is thought to consist of three nucleoporins, Nup54, Nup58, and Nup62. However, the structure and composition of the channel are elusive. We determined the crystal structures of the interacting domains between these nucleoporins and pieced together the molecular architecture of the mammalian transport channel.
