Nature Genetics: January 22, 2012
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Nature Genetics online: January 22, 2012
Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
Paul Delgado-Olguín, Yu Huang, Xue Li, Danos Christodoulou, Christine E. Seidman, J.G. Seidman, Alexander Tarakhovsky and Benoit G. Bruneau
We show that Ezh2 stabilizes cardiac gene expression and prevents cardiac pathology by repressing the homeodomain transcription factor gene Six1, which functions in cardiac progenitor cells but is stably silenced upon cardiac differentiation. Our results suggest that epigenetic dysregulation in embryonic progenitor cells is a predisposing factor for adult disease and dysregulated stress responses.
