Science 335: 1617-1621 (March 30, 2012)
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Science 335: 1617–1621
Control of sleep by cyclin A and its regulator
Dragana Rogulja and Michael W. Young
We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster. Reducing the abundance of CycA in neurons delayed the wake-sleep transition, caused multiple arousals from sleep, and reduced the homeostatic response to sleep deprivation.
