Scientists have identified the mechanism that allows skin cells to sense changes in their environment, and very quickly respond to reinforce the skin's outermost layer. The findings provide insight into how errors in this process might lead to skin conditions like psoriasis.
The novel compounds are based on so-called broadly neutralizing antibodies, molecules that make rare people's immune systems capable of fighting HIV. They could potentially yield new treatment and prevention approaches benefitting people around the world, including in developing countries.
Scientists have identified a particular type of skin cell that looks and behaves similar to a nerve cell, prompting new questions about the body's biggest organ.
For reasons that have long been unclear, cells stop dividing when the pH rises inside tiny cellular compartments called lysosomes. Now scientists have found an explanation for this phenomenon, with potential implications for drug development.
Protein clumps are routinely found in the brains of patients with neurodegenerative diseases. Now researchers find a link between this buildup and the intracellular movement of proteasomes, molecular machines tasked with degrading protein waste inside cells.
Research that began with the analysis of two developmental syndromes ultimately helped scientists understand how diverse epigenetic mechanisms can combine to drive tissue overgrowth in cancer.
A new study finds that neurons affected in Parkinson’s disease can shut down without fully dying, allowing them to also switch off neighboring cells. The findings might give scientists a better understanding of how the condition wreaks havoc in the brain, as well as ideas for new treatments.
To grow new hair, stem cells throughout the skin must work in sync. Researchers have discovered the molecular communication tool, part of the lymphatic system, that the cells use to synchronize their activities.
Allis, whose pioneering research established that enzymes that modify histone proteins, which package DNA in the nucleus, regulate gene expression, has been elected to the National Academy of Medicine.
