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Research details how developing neurons sense a chemical cue

Symmetry is an inherent part of development. As an embryo, an organism’s brain and spinal cord, like the rest of its body, organize themselves into left and right halves as they grow. But a certain set of nerve cells do something unusual: they cross from one side to the other. New research in mic...

Science online: May 29, 2014

Science online: May 29, 2014 Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism Kai Xu, Zhuhao Wu, Nicolas Renier, Alexander Antipenko, Dorothea Tzvetkova-Robev, Yan Xu, Maria Minchenko, Vincenzo Nardi-Dei, Kanagalaghatta R. Rajashankar, Juha Himanen, M...

Nature 509: 637–640 (14-5-29)

Nature 509: 637–640 Clonal selection in the germinal centre by regulated proliferation and hypermutation Alexander D. Gitlin, Ziv Shulman and Michel C. Nussenzweig

In the News

Obama Meets 18-Year-Old Cancer Researcher, Among Other Science-Fair Achievers   "President Barack Obama lauded whiz kids at the White House Science Fair on Tuesday, including Elana Simon [daughter of Sanford Simon], an 18-year-old who helped research a rare liver cancer that she was diagnosed wit...

Cell 157: 1230-1242 (14-5-22)

Cell 157: 1230-1242 Molecular profiling of neurons based on connectivity Mats I. Ekstrand, Alexander R. Nectow, Zachary A. Knight, Kaamashri N. Latcha, Lisa E. Pomeranz and Jeffrey M. Friedman

Researchers profile active genes in neurons based on connections

When it comes to the brain, wiring isn’t everything. Although neurobiologists often talk in electrical metaphors, the reality is that the brain is not nearly as simple as a series of wires and circuits. Unlike their copper counterparts, neurons can behave differently depending on the situation. R...

Proceedings of the National Academy of Sciences USA 111: 7325-7330 (14-05-20)

Proceedings of the National Academy of Sciences USA 111: 7325-7330 Histone variant H3.3 is an essential maternal factor for oocyte reprogramming Duancheng Wen, Laura A. Banaszynski, Ying Liu, Fuqiang Geng, Kyung-Min Noh, Jenny Xiang, Olivier Elemento, Zev Rosenwaks, C. David Allis and Shahin Rafii

In the News

Hacking the mind: How to harness the power of the body's greatest tool   "Ultimately, the neuroscience experts concluded, for all the research and progress that’s been done about the brain and its many powers, there’s still a far way to go. 'It's like the space program except it's inner-space ...

Searching for drugs in dirt, researchers call on citizen scientists

Microbes are not only a rich source of disease, but also a rich source of medicines, and experts think many life-saving compounds produced by as-yet-unnamed bacteria are awaiting discovery. But they don’t always give up their secrets easily. Researchers must know where to look to find promising b...

Rockefeller ranks first in scientific impact among list of global institutions

The Rockefeller University has the highest percentage of frequently cited scientific publications of 750 top universities worldwide, according to the CWTS Leiden Ranking, which measures citation impact and scientific collaboration. The ranking, conducted by the Center for Science and Technology S...