More than 10 percent of people who develop severe COVID-19 have misguided antibodies that attack not the virus, but the immune system itself, new research shows. Another 3.5 percent, at least, carry a specific kind of genetic mutation. In both groups, the upshot is basically the same: The ...
...In recent studies, elevated IL24 activity has been spotted in epithelial lung tissue of patients with severe COVID-19 and in colonic tissue in patients with ulcerative colitis, a chronic inflammatory bowel disease. “IL24 could be working as a cue to signal the need for injury repair in ...
...Research aimed to understand how COVID-19 wreaks havoc in the lungs, for example, has often been done with miscellaneous lung cancer cells that show crucial differences with the cells targeted by the virus. “There has been too much shifting ground for precise work,” says Ali H. Brivanlo...
...Casanova, along with Helen Su at the National Institute of Allergy and Infectious Diseases are leading an international project, the COVID Human Genetic Effort, to comb through the genomes of many COVID-19 outliers in search of any rare gene variant that they may share, and that ...
In more ways than one, antibodies could be the key to alleviating the COVID-19 crisis. Hundreds of labs around the world are studying the antibodies people produce in response to SARS-CoV-2 infection in hopes of developing treatments, predicting the efficacy of vaccines, and understanding...
...The dysregulation of the contact system is involved in COVID, sickle cell anemia, hereditary angioedema, inflammatory bowel disease, sepsis, lupus, arthritis, and even cancer metastasis,” she says.
In the few weeks since New York City came to a socially distanced halt, more than 250 COVID-19 survivors have visited Rockefeller’s otherwise quiet campus to contribute their blood to science. Here, a group of immunologists, medical scientists, and virologists is betting that a cure for th...
As the world faces an impending wave of COVID cases due to Omicron, scientists are racing to assess vaccine efficacy against the new variant. In a new study, Rockefeller scientists report on their comprehensive analysis of Omicron’s resistance to antibodies, offering insights about the lev...
...The findings shed new light on how the immune system mounts a response against infections such as COVID and HIV. "Germinal centers are open structures that continuously receive B cells," says Michel C. Nussenzweig, the Zanvil A. Cohn and Ralph M. Steinman Professor at Rockefeller. "As t...
According to new research, people who have had COVID enjoy strong immunity against the coronavirus for at least a year after they were initially infected. In analyzing antibodies present in the blood of COVID patients, Rockefeller scientists were able to track the evolution of these...
