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Research explains how cellular guardians of the gut develop
Even the most careful chosen meal can contain surprises. To defend against infectious microbes, viruses or other potential hazards that find their way to the intestines, a dedicated contingent of immune cells keeps watch within the thin layer of tissue that divides the contents of the gut from th...
Antibodies, together with viral ‘inducers,’ found to control HIV in mice
Although HIV can now be effectively suppressed using anti-retroviral drugs, it still comes surging back the moment the flow of drugs is stopped. Latent reservoirs of HIV-infected cells, invisible to the body’s immune system and unreachable by pharmaceuticals, ensure that the infection will reboun...
An embryonic cell’s fate is sealed by the speed of a signal
When embryonic cells get the signal to specialize the call can come quickly. Or it can arrive slowly. Now, new research from Rockefeller University suggests the speed at which a cell in an embryo receives that signal has an unexpected influence on that cell’s fate. Until now, only concentration o...
Small RNAs in blood may reveal heart injury
Like clues to a crime, specific molecules in the body can hint at exposure to toxins, infectious agents or even trauma, and so help doctors determine whether and how to treat a patient. In recent years, tiny pieces of RNA called microRNAs have captured scientific attention for their potential as ...
Discovery of pro-metastasis protein reveals mysterious link to neurodegeneration
Researchers have identified a protein that makes breast cancer cells more likely to metastasize. What's more, the protein appears to trigger cancer's spread in part by blocking two other proteins normally linked to neurodegeneration, a finding that suggests a tie between two of the most common di...
Researchers create the first model of the DNA ‘replication fork’
Human cells make new copies of their DNA billions of times each day, a crucial process upon which life itself depends. However, scientists do not fully understand how cells unzip the double-stranded DNA molecule before replicating both halves of it. New work at Rockefeller may help change that. F...
Genetically driven gut feelings help female flies choose a mate
Even among flies, mating is a complicated ritual. Their elaborate, and entirely innate, courtship dance combines multiple motor skills with advanced sensory cues. Now, researchers at Rockefeller University have determined that the Abdominal-B (Abd-B) gene, previously known as the gene that sculpt...
Using geometry, researchers coax human embryonic stem cells to organize themselves
About seven days after conception, something remarkable occurs in the clump of cells that will eventually become a new human being. They start to specialize. They take on characteristics that begin to hint at their ultimate fate as part of the skin, brain, muscle or any of the roughly 200 cell ty...
Potential Alzheimer’s drug prevents abnormal blood clots in the brain
Without a steady supply of blood, neurons can’t work. That’s why one of the culprits behind Alzheimer’s disease is believed to be the persistent blood clots that often form in the brains of Alzheimer’s patients, contributing to the condition’s hallmark memory loss, confusion and cognitive ...
Sequencing efforts miss DNA crucial to bacteria’s disease causing power
Genomic sequencing is supposed to reveal the entire genetic makeup of an organism. For infectious disease specialists, the technology can be used to analyze a disease-causing bacterium to determine how much harm it is capable of causing and whether or not it will be resistant to antibiotics. But ...
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