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By tracking water molecules, physicists hope to unlock secrets of life

The key to life as we know it is water, a tiny molecule with some highly unusual properties, such as the ability to retain large amounts of heat and to lose, instead of gain, density as it solidifies. It behaves so differently from other liquids, in fact, that by some measures it shouldn’t eve...

Brain arousal heightens sexual activity in male mice

The most powerful sexual organ, it’s said, is the brain. Now here’s the evidence. New research from Rockefeller University shows that an overly excitable brain hastens sexual activity in male mice and increases their nervous energy, a finding that not only points to the existence of a centra...

Researchers track evolution and spread of drug-resistant bacteria across hospitals and continents

An international team of researchers has used high resolution genome sequencing to track a particularly virulent strain of MRSA as it traveled between South America, Europe and Southeast Asia. The findings shed light on how these deadly bacteria are able to spread from patient to patient in a sin...

First evidence that the brain’s native dendritic cells can muster an immune response

The human brain is a delicate organ, robustly defended. A thick skull shields it from any direct exposure to the outside world, and the blood-brain barrier keeps out any foreign substances that are circulating within. New research shows that the brain may have its own specialized immune defenses,...

Clinical trial to explore link between vitamin D and cholesterol

An unusual finding in previous studies of vitamin D-deficient patients has prompted Rockefeller University researchers to launch a new clinical study to determine whether there is a causative link between vitamin D supplementation and changes in cholesterol levels in people at risk for cardiovasc...

Loosely coiled DNA helps trypanosomes make their escape

To escape the grip of the human immune system, Trypanosoma brucei, which causes African sleeping sickness, performs its acclaimed disappearing act. Every time the host’s immune cells get close to eliminating the infection, a small number of trypanosomes avoid detection by changing their surface ...

Loss of epigenetic regulators causes mental retardation

Developing neurons don’t just need the right genes to guide them as they grow, they need access to the right genes at the right times. The improper functioning of one specific protein complex that normally suppresses gene activation is responsible for a mental retardation-like syndrome in mice, r...

DNA ‘barcoding’ reveals 95 species of life in NYC homes, students show

Two New York City high school students exploring their homes using the latest high-tech DNA analysis techniques were astonished to discover a veritable zoo of 95 animal species surrounding them, in everything from fridges to furniture. Guided by DNA “barcoding” experts at The Rockefeller Univer...

Scientists visualize how a vital hepatitis C virus protein moves along its nucleic acid substrate

By taking three conformational snapshots of a hepatitis C virus motor protein in association with its substrate, researchers at Rockefeller University have provided the first structural explanation of how a representative superfamily 2 helicase moves unidirectionally along nucleic acid, suggestin...

Genomic differences identified in common skin diseases

It’s sometimes said that dermatologists do one of two things (though it’s not dermatologists who say it): Faced with a skin disease that’s too dry, they try to wet it; if the disease is too wet, they try to dry it. There’s some wisdom in this general approach, says James G. Krueger, head of ...