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Science News

Two proteins act as molecular tailors in DNA repair

Every day tiny segments of our DNA are chipped or fragmented or get stuck together when they should really be pulled apart. But what our genome necessarily lacks in stability it makes up for with a phalanx of guards that monitor and repair the damage. In new research to appear in this week’s adva...
Science News

High fat diet increases inflammation in the mouse colon

Colorectal cancer, the third most common type of cancer worldwide, has been linked to an increased prevalence of the Western diet: one high in fat and low in fiber, vitamin D and calcium. Now, a team of scientists led by researchers at Rockefeller University have shown what happens to colon tissu...
Science News

Scientists reveal a new mechanism that increases atherosclerosis in mice

A shot of espresso may rev you up in the morning, but the downside is that it may also ramp up levels of bad cholesterol due to its effects on a unique liver protein called PXR. New research from Rockefeller University now shows that when chronically activated, the protein rejiggers how cholester...
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Immune system uses a “leash” to restrict HIV’s spread

Measure. Countermeasure. So the war against a virus unfolds. The immune system comes up with one defense and the invader finds a way to thwart it. New research on HIV details a new example of this ongoing struggle, showing that the immune system produces an antiviral protein called tetherin that ...
Science News

Disrupting sleep causes problems for the body and brain

Anyone who has pulled an all-nighter or flown across an ocean knows you can’t mess up your sleep schedule without unpleasant consequences. New research in mice now shows that throwing off natural circadian rhythms over the long term can seriously disturb the body and brain, causing weight gain an...
Science News

Checkered history of mother and daughter cells explains cell cycle differences

When mother and daughter cells are created each time a cell divides, they are not exactly alike. They have the same set of genes, but differ in the way they regulate them. New research now reveals that these regulatory differences between mother and daughter cells are directly linked to how they ...
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Transgenic songbirds provide new tool to understand the brain

You can learn a lot from an animal. By manipulating the DNA of mice, flies, frogs and worms, scientists have discovered a great deal about the genes and molecules behind many of life’s essential processes. These basic functions often work about the same in people as they do in “model” animals....
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“Promiscuous” protein interactions found in the nuclear pore complex

In higher organisms, cells are very selective about what passes in and out of their nuclei, where the genes reside. This selectivity helps protect the DNA and is the job of machines that stud the envelope of the nucleus, called nuclear pore complexes. These gatekeepers have proved largely inscrut...
Science News

Clinical study to probe genetic link to Salmonella diseases

Depending on your genes, Salmonella can mean a lot more than food poisoning. In a new clinical study, researchers at The Rockefeller University Hospital are narrowing in on the genetic link that predisposes a person to a set of complications known as severe nontyphoidal salmonellosis (SNTS). The ...
Science News

New model suggests how the brain might stay in balance

The human brain is made up of 100 billion neurons — live wires that must be kept in delicate balance to stabilize the world’s most magnificent computing organ. Too much excitement and the network will slip into an apoplectic, uncomprehending chaos. Too much inhibition and it will flatline. A new...
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