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Science News

New method exploits old mechanism to turn genes on and off at will

Since our ancestors first harnessed fire, we’ve used heat to cook burgers, forge steel and power rockets. Now, Rockefeller University researchers are using heat for another purpose: turning genes on and off at will. By exploiting the heat shock response, an ancient mechanism that protects cells f...
Science News

Cells use Velcro-like mechanism to keep viruses from spreading

Like mobsters, cells keep their friends close and their enemies — at least some of them — closer. According to new results from HIV researchers at Rockefeller University, one way that human cells prevent certain viruses from raging out of control is by blocking new viral particles from ever leav...
Science News

Small experience during critical period alters brain

Unlike the circuitry of the visual system, that of the olfactory system was thought to be hardwired: Once the neurons had formed, no amount of sensory input could change their arrangement. Now researchers at Rockefeller University and their collaborators have upturned this scientific dogma by sho...
Science News

Rendering of ion channel suggests how neurons fire

Four years ago, Roderick MacKinnon, head of the Laboratory of Molecular Neurobiology and Biophysics at Rockefeller University, together with several members of his lab, published the first ever structure of a voltage-dependent potassium ion channel — a protein that controls the flow of potassium ...
Science News

Multi-lab collaboration yields first detailed map of nuclear pore complex

A cell’s membrane-bound nucleus contains precious contents — its DNA — so it must be very careful about what enters and leaves this important space. To do this, it uses hundreds to thousands of nuclear pores as its gatekeepers, selective membrane channels that are responsible for regulating th...
Science News

Data suggest community involvement is the key to controlling infectious disease

The battles against infectious diseases are challenging enough in Western countries with stable infrastructure and deep-pocketed pharmaceutical firms. In an impoverished section of Latin America, they are much more difficult. But new research from Rockefeller University’s Joel E. Cohen suggests t...
Science News

Recently discovered cell is unexpected player in psoriasis

When the FDA assesses a drug, it looks closely at its safety and its effectiveness, but it doesn’t require a precise understanding of how the drug works. A new study by Rockefeller University scientists shows that a strikingly successful psoriasis drug, etanercept, may not act on the immune cells...
Science News

Stress response in the brain relies on a blood-thinning protein

A stressed-out mouse tends to be a bit timid, tentative, even fearful. For that matter, so does a stressed-out human. Our ability to learn from frightening situations is part of what helps us avoid them in the future. When that learning process goes awry, it can lead to depression and a decreased...
Science News

A protein converts immune cells to tumor killers

Tumor cells are masters at evading detection. But new research from Rockefeller University shows how they can be exposed. By harnessing the immune system of patients with a rare neurological disorder, scientists have figured out how to transform immune cells that barely detect the presence of bre...
Science News

Biologists use microfluidics chips to watch worm behavior

Tiny roundworms called Caenorhabditis elegans have a rather uncomplicated method for finding food: They wriggle and turn and explore new territory until they find something edible, and then they stay the course until the food disappears. But despite the worm’s simple nervous system, researchers ...
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