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Ion channels are key to estrogen's effect on neurons
Despite being one of the body's best-studied hormones, there's still a lot we don't know about estrogens. Now, by studying how these sex hormones impact brain cells at the biophysical level, scientists at Rockefeller University say they exert their powerful effects on behavior in part by affectin...
Measuring awareness is not as simple as a single number
Science fiction describes the crucial difference between a robot and a person as sense of self. But for Rockefeller University’s George Reeke, computers — self or no self — do not yet begin to capture the complexity of the human mind. An article by Reeke and coauthors published recently in Pr...
HIV-1 kills immune cells in the gut that may never bounce back
People with HIV have been living longer, healthier lives since the development of highly active antiretroviral therapy (or HAART) in 1995. In fact, most patients on the drug regimen do so well that, according to blood tests, their immune cells appear to return to pre-HIV levels. But two new studi...
Newly discovered class of small RNAs is specifically to reproductive cells
One size does not fit all when it comes to RNA. And now, in addition to long mRNA strands that deliver genetic instructions, and microRNAs (miRNAs) that serve to tweak those instructions and are implicated in everything from insulin production to cancer, scientists have discovered a new player am...
Structure shows how a key protein in gene activation is controlled
Having good genes is not enough; they each need to be expressed at the right time and place. By solving the structure of a protein called σ, researchers at Rockefeller University reveal a new mechanism by which bacteria prevent premature and precocious activation of their genes. Bacteria use the ...
Rockefeller lab show that Notch signaling is involved in multiple skin fate decisions
To serve as an effective barrier, skin must form multiple layers that separate internal organs from exposure to the environment. New research from Rockefeller University shows that a well-known signaling pathway, Notch, drives the process by which skin cells form those layers. Starting with the i...
In mice, a new statistical analysis shows a sex hormone influences a drive to explore
Exhaustive searching may not guarantee a compatible mate, but that doesn’t stop most people from trying. Now, new research from Rockefeller University suggests that estrogens may be a driving force. Research in mice, led by George Reeke and Donald Pfaff, has shown that this family of sex hormones...
Dendritic cells stimulate cancer-cell growth
Since their discovery at Rockefeller University some 30 years ago, dendritic cells have been recognized as key players on the immune-system team, presenting antigens to other immune cells to help them respond to novel insults. Now, Rockefeller scientists have shown that dendritic cells also have ...
New gene-slicing method targets specific areas of the brain
To understand the role any one gene plays in an organism, scientists rely on knockout mice: They breed a mouse that lacks the gene they are interested in, then observe the effects. It doesn’t always work. Removing a gene from an entire mouse can create many problems, including killing the mouse b...
New look at world's forests shows many are expanding
For years, environmentalists have been raising the alarm about deforestation. But even as forests continue to shrink in some nations, others grow — and new research suggests the planet may now be nearing the transition to a greater sum of forests. A new formula to measure forest cover, developed ...
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