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Science News

Structural study shows how bacteria select their most virulent proteins

Salmonella poisoning, dysentery, the plague, typhoid fever, and a number of other serious ailments are caused by a diverse group of bacterial pathogens that have one thing in common: They all use the same syringe-like system to infect their hosts. Known as a “type III secretion system,” this tra...
Science News

By targeting dendritic cells, HIV and malarial vaccines outperform competitors

Although DNA-based vaccines are often in the limelight, scientists at Rockefeller University are developing a completely different approach to inducing immunity, one that directs a vaccine straight to the immune cells of living animals and, eventually, humans. In two papers published this month i...
Science News

MicroRNAs linked to mammalian skin development

Since their discovery, microRNAs have been shown to play a role in the development of many organisms, including plants and insects but, until now, no one had linked them to developmental processes in humans or other mammals. This week, new research from Rockefeller University firmly establishes m...
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Genetic 'stress response' may explain how bacteria resist drugs

Antibiotics are great, when they work. Unfortunately, bacteria have a nasty habit of developing resistance to even our most powerful pharmaceuticals. Now, by tracking the staph infection of a single patient during a course of antibiotic treatment, Rockefeller University scientists have discovered...
Science News

Modular structure enables TRCF protein to both halt transcription and repair DNA

veryone needs a little push now and then. Even proteins. In new research from Seth Darst’s lab at Rockefeller University, the structure of one of the pushiest proteins in bacteria is finally brought to light. Among the most stable complexes in a cell is the attachment between DNA and RNA polymera...
Science News

Damaged tumor suppressor plays major role in lymphoma development

Scientists have known for years that chromosomal translocations — abnormalities in which a piece of one chromosome breaks off and fuses to another — lead to a type of blood cancer called lymphoma, but little was known about how cells accumulate translocations or defend themselves against them. N...
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PLD1 protein is implicated in Alzheimer's brain damage

Most current Alzheimer’s drugs target molecules responsible for memory formation. But while helpful at slowing and even reversing memory loss, this approach doesn’t address the root of the problem: plaques that build amid brain cells, causing them to weaken and die. In back-to-back papers pub...
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Genetic studies in mice yield clues to how heart disease is inherited

Heart disease tends to run in families, and scientists have long known that genetics play an important role. Now, new research in mice, from the laboratory of Rockefeller’s Jan L. Breslow, shows that the genetics of heart disease are more complicated than previously thought. In a study led by Dan...
Science News

Newly discovered immune cell partially responsible for psoriasis

In a discovery that may help shape new treatments for psoriasis, scientists at Rockefeller University have found a new type of immune cell that may be critical in producing inflammation and tissue damage in the skin. Psoriasis occurs when white blood cells react to an unknown trigger and inappro...
Science News

'Geneless' enzyme is key to how bacteria intack

To infect, bacteria must first stick. Several proteins on their cell wall surface are there simply to attach themselves to the surrounding tissues of their hosts, such as the warm, moist, inviting ones at the back of your throat. Now new research from Sung Lee and Vincent Fischetti in Rockefeller...
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