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Proceedings of the National Academy of Sciences USA online: April 28, 2014

Proceedings of the National Academy of Sciences USA online: April 28, 2014 Structure of the branched intermediate in protein splicing Zhihua Liu, Silvia Frutos, Matthew J. Bick, Miquel Vila-Perelló, Galia T. Debelouchina, Seth A. Darst and Tom W. Muir

Cell 157: 636-650 (14-4-24)

Cell 157: 636-650 Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function Ender Karaca, Stefan Weitzer, Davut Pehlivan, Hiroshi  Shiraishi, Tasos Gogakos, Toshikatsu Hanada, Shalini N. Jhangiani, Wojciech Wiszniewski, Marjorie Withers, Ian M. Camp...

Proceedings of the National Academy of Sciences USA online: April 24, 2014

Proceedings of the National Academy of Sciences USA online: April 24, 2014 A model for the generation and transmission of variations in evolution Olivier Rivoire and Stanislas Leibler
Science News

Friction harnessed by proteins helps organize cell division

A football-shaped structure, known as the mitotic spindle, makes cell division possible for many living things. This piece of cellular architecture, responsible for dividing up genetic material, is in constant flux. The filaments that form it grow and shrink, while motor-like molecules burn energ...
Science News

A new web tool effectively prioritizes disease-causing genes by biological distance

A new tool, essentially a genetic navigation system that can help biologists identify connections and measure distances between human genes, has received an upgrade. Now, just as with Google Maps, anyone can access the Human Gene Connectome, without training in computational biology or the need t...
Science News

Genetically identical ants help unlock the secrets of larval fate

A young animal’s genes are not the only genes that determine its fate. The genetic identity of its caretakers matters too. Researchers suspect the interaction between the two can sway the fate of the young animal, but this complex dynamic is difficult to pin down in lab experiments. However, soci...

Cell 157: 420-432 (14-4-10)

Cell 157: 420-432 Asymmetric friction of nonmotor MAPs can lead to their directional motion in active microtubule networks Scott Forth, Kuo-Chiang Hsia, Yuta Shimamoto and Tarun M. Kapoor

Proceedings of the National Academy of Sciences USA 111: 1393-1401 (14-4-8)

Proceedings of the National Academy of Sciences USA 111: 1393-1401 Dynamic gene expression by putative hair-cell progenitors during regeneration in the zebrafish lateral line Aaron B. Steiner, Taeryn Kim, Victoria Cabot and A. J. Hudspeth

Nature Genetics online: April 6, 2014

Nature Genetics online: April 6, 2014 Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations Pawel Buczkowicz, Christine Hoeman, Patricia Rakopoulos, Sanja Pajovic, Louis Letourneau, Misko Dzamba, Andrew Morrison, Peter ...
Science News

Drug is identified that could block the spread of melanoma

Cancer is at its most curable when it’s caught before it spreads. That’s especially true in the case of melanoma, where survival rates can be as high as 97 percent when caught early — and as low as 15 percent if it’s not. New research at Rockefeller has now identified a promising route to sl...
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