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Developing neurons reverse direction in absence of Wnt protein
There are 10 billion neurons in the human brain, with 10 trillion connections, and in this complex web, every bit of information must be routed along the correct path. But despite years of study, scientists don’t fully understand how the body forms the neural pathways that route that information....
Aggravated assault: How adhesion proteins regulate skin inflammation
When it comes to skin, the tighter the better. To create an effective barrier, cells in the epidermal, or outermost, layer of the skin form very tight associations. But while strong links between skin cells protect the body from the world outside, new research from Rockefeller University shows th...
Structural study shows how bacteria select their most virulent proteins
Salmonella poisoning, dysentery, the plague, typhoid fever, and a number of other serious ailments are caused by a diverse group of bacterial pathogens that have one thing in common: They all use the same syringe-like system to infect their hosts. Known as a “type III secretion system,” this tra...
By targeting dendritic cells, HIV and malarial vaccines outperform competitors
Although DNA-based vaccines are often in the limelight, scientists at Rockefeller University are developing a completely different approach to inducing immunity, one that directs a vaccine straight to the immune cells of living animals and, eventually, humans. In two papers published this month i...
Rockefeller neurobiologist to receive Benjamin Franklin Medal
Rockefeller University’s Fernando Nottebohm will receive the 2006 Benjamin Franklin Medal in Life Science, The Franklin Institute in Philadelphia announced today. The medal recognizes Nottebohm’s discovery of neuronal replacement in the adult vertebrate brain and the elaboration of the mechanism...
MicroRNAs linked to mammalian skin development
Since their discovery, microRNAs have been shown to play a role in the development of many organisms, including plants and insects but, until now, no one had linked them to developmental processes in humans or other mammals. This week, new research from Rockefeller University firmly establishes m...
Genetic 'stress response' may explain how bacteria resist drugs
Antibiotics are great, when they work. Unfortunately, bacteria have a nasty habit of developing resistance to even our most powerful pharmaceuticals. Now, by tracking the staph infection of a single patient during a course of antibiotic treatment, Rockefeller University scientists have discovered...
Modular structure enables TRCF protein to both halt transcription and repair DNA
veryone needs a little push now and then. Even proteins. In new research from Seth Darst’s lab at Rockefeller University, the structure of one of the pushiest proteins in bacteria is finally brought to light. Among the most stable complexes in a cell is the attachment between DNA and RNA polymera...
Damaged tumor suppressor plays major role in lymphoma development
Scientists have known for years that chromosomal translocations — abnormalities in which a piece of one chromosome breaks off and fuses to another — lead to a type of blood cancer called lymphoma, but little was known about how cells accumulate translocations or defend themselves against them. N...
PLD1 protein is implicated in Alzheimer's brain damage
Most current Alzheimer’s drugs target molecules responsible for memory formation. But while helpful at slowing and even reversing memory loss, this approach doesn’t address the root of the problem: plaques that build amid brain cells, causing them to weaken and die. In back-to-back papers pub...
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