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CLIP-ping the messenger In journal Science, researchers describe new technique for cataloging RNA targets in rare brain disease New method may apply to diseases such as Fragile X mental retardation RNA, often thought of as merely the chemical messenger that helps decode DNA's genetic instructions...

To get its job done, each cell in the human body must constantly change its inner skeleton and therefore its outer shape. This skeleton also serves as a vast network of "tracks," which grow and shrink and move in different directions as needed to transport proteins and other materials within the ...

Unprecedented genetic access to brain provided by Rockefeller University scientists For scientists studying the brain, this week's Nature announces a remarkable new map describing previously uncharted territory, plus the means of exploring the new horizons for themselves. Rockefeller University s...

Using "knockout" mice and mutant roundworms, researchers at The Rockefeller University and the University of California, San Francisco, have identified a protein that helps control water balance in the body and underlies the sensation of touch — functions basic to life that have long eluded expla...

Immune system provides new clue to most life-threatening bacterium The microbe that causes tuberculosis operates the way a human terrorist would. With minimal resources, the TB bacterium skillfully blends in and gains strength before lashing out unexpectedly. This microbe, which claims more human...

Nation's highest scientific award honors gene regulation pioneer James E. Darnell Jr., M.D., a pioneering researcher in the field of gene regulation, will receive the National Medal of Science, the White House announced today. Darnell is among eight American scientists to receive the award, the n...

Rockefeller University Professor Roderick MacKinnon, M.D., a biophysicist and X-ray crystallographer whose exquisitely detailed portraits of a class of proteins explain the generation of nerve impulses — the electrical activity that underlies all movement, sensation and thought — is honored this...

New theory explains how gene-silencing "glue" can be removed In addition to nails and screws, a carpenter's bag of tricks includes glue. Nails can be pulled, screws can be removed, but glue is typically permanent. Nature uses its own version of glue to jam a gene's expression when its activity co...

Gleevec, the breakthrough drug for treating chronic myologenous leukemia (CML) and gastrointestinal stromal tumors, slowed the accumulation of the major protein component of senile plaques that characterize Alzheimer's disease, in laboratory cultures of mouse brain cells and guinea pigs. The find...

Salmonella, a well-known food-borne bacterium, uses protein "staples" to restructure the shape of the gut cells it invades, forcing these cells to flow around the bacteria and engulf them, researchers at Rockefeller University have discovered. The research, published in the September 26 issue of ...