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New Method Enables Multiplex Genome Engineering "A consortium of scientists [including The Rockefeller University] announced that they had devised a way to enable simultaneous editing of several sites within the mammalian genome. The technology, based on a bacterial defense system against viruses...

Molecular Cell online: January 1, 2013 53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma Mila Jankovic, Niklas Feldhahn, Thiago Y. Oliveira, Israel T.  Silva, Kyong-Rim Kieffer-Kwon, Arito Yamane, Wolfgang Resch, Isaac Klein, Davide F. Robbiani, Rafael Ca...

Proceedings of the National Academy of Sciences USA online: December 31, 2012 Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase Rebecca K. Delker, Yanjiao Zhou, Alexandros Strikoudis, C. Erec Stebbins and F. Nina Papavasiliou

Molecular Cell online: December 22, 2012 An H3K36 methylation-engaging tudor motif of polycomb-like proteins mediates PRC2 complex targeting Ling Cai, Scott B. Rothbart, Rui Lu, Bowen Xu, Wei-Yi Chen, Ashutosh Tripathy, Shira Rockowitz, Deyou Zheng, Dinshaw J. Patel, C. David Allis, Brian D. Stra...

Molecular Cell online: December 27, 2012 Activation of DSB processing requires phosphorylation of CtIP by ATR Shaun E. Peterson, Yinyin Li, Foon Wu-Baer, Brian T. Chait, Richard Baer, Hong Yan, Max E. Gottesman and Jean Gautier

Proceedings of the National Academy of Sciences USA 109: 21319-21324 Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes Shaun D. McCullough, Xiaojiang Xu, Sharon Y. R. Dent, Stefan  Bekiranov, Robert G. Roederc and Patrick A. Grant

With the global population racing past seven billion, demographers and world leaders have been concerned with depletion of resources to support everyone. The future, though, may be less bleak than some have feared. Changes in population growth and how farmers use land have brought the world to “p...

Cell 151: 1417-1430 MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system Marian Mellén, Pinar Ayata, Scott Dewell, Skirmantas Kriaucionis and Nathaniel Heintz

Is the Cure for Cancer Inside You?   "In the long struggle that was to come, [Ralph] Steinman would try anything and everything that might extend his life, but he placed his greatest hope in a field he helped create, one based on discoveries for which he would earn his Nobel Prize. He hoped to re...

Farmland Peaks, Crop Space to Revert Back to Nature, Report Finds   "Humanity has reached what Rockefeller University scientists, in a new report, call 'peak farmland.' In the next half-century, a geographical area more than twice the size of France — or equivalent to 10 Iowas — will return to...