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"Genome destroyer" identified in the immune system
Enzyme called AID is the initial culprit in B cell cancers Our bodies have such great capacity to heal, it's hard to imagine that we naturally manufacture a product in our immune system that can endanger our own DNA and provide a biological footstep to cancer. But this is precisely the case. In t...
Hormone replacement therapy one hour at a time
Rodent study suggests approach to keep good and lose bad effects of standard hormone treatments Giving hormone doses in pulses, rather than as a steady exposure, may maximize the benefits and limit the side effects now associated with hormone therapies. This is one implication of the findings sci...
Viral locksmith is caught in the act
Interactions between viral and bacterial proteins promise new directions for antibiotics How does the molecular machine responsible for activating genes choose which gene to switch on, from among the 30,000 genes contained in each cell of the human body? In the August 4 issue of the EMBO Journa...
Rockefeller University establishes stem cell research center
                $5 million endowment by NYC philanthropist Harriet Heilbrunn for research to advance basic research knowledge about stem cells   For more information about Rockefeller research using stem cells, visit http://www.rockefeller.edu/stemcell.   With the support of...
Through population screening on the island of Kosrae, Rockefeller scientists discover a mutant gene that controls dietary cholesterol absorption
Findings may contribute to revealing genetic underpinnings of high cholesterol Using DNA from 1,000 inhabitants of the Micronesian island of Kosrae, Rockefeller University scientists have discovered a mutant gene that affects an individual's absorption of dietary cholesterol. The findings are rep...
Preparing for a safe split
Rockefeller scientists show how cells establish the correct line-up of chromosomes before they divide As it prepares to divide, a human cell makes exact copies of all of its 46 chromosomes, so that the two daughter cells each can have a complete set of genetic material. The two sets must separate...
Activation of tumor suppressor gene p53 much more complex than previously believed
It's the biochemist's twist on the old light bulb jokes: how many proteins does it take to activate a gene? Scientists in Robert Roeder's Laboratory of Molecular Biology and Biochemistry at Rockefeller University now know that, at least for gene activation by the tumor suppressor p53, the answer ...
Lab mice rescued from Type 1 diabetes via dendritic cell-assisted therapy
Research reveals impending autoimmunity can be stopped Rockefeller University researchers have for the first time demonstrated a halting of early Type 1 diabetes in mice by restoring a critical class of T cells to their normal balance. The findings, reported in the June 7 issue of theJournal of ...
Cell growth and death controlled by a single pathway in lymphoma cancer model
Researchers provide first molecular description of a cancer caused by bacteria New research at Rockefeller University, published this week in the online edition of the Proceedings of the National Academy of Sciences, helps explain why some people do not respond to chemotherapy and offers a possib...
Molecular image of genotoxin reveal how bacteria damage human DNA
The three-dimensional structure of a DNA-damaging, bacterial toxin has been visualized by scientists at Rockefeller University. The molecular image of the toxin, published in the May 27 issue of the journalNature, shows exactly how the toxin is put together at the molecular level and damages huma...
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