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More Studies Shed Light on How Prozac Works

Nobel laureate Paul Greengard, Ph.D., and other Rockefeller University scientists have illuminated, in laboratory mice, new details of the complex chemical interaction in the brain that is generated by Prozac, the widely prescribed drug for depression. Their findings are reported in a pair of pap...
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Cells on the Verge of Suicide

Rockefeller Scientist discovers molecular messengers that rescue cells from death A developing cell in the human body sits on the edge of death. Proteins called Grim, Reaper and Hid stand poised, ready to unleash other toxic proteins. Only if a protein messenger from another cell arrives in time ...
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Tidying Up Transcription Factors

Researchers reclassify key protein players of the cell Fifty years ago, in the early days of biology, so little was known about the cell that all of the proteins outside of its nucleus were grouped into one big "cytoplasmic soup." Now, as the list of known cellular ingredients continues to expand...
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Pioneering Genome Analysis Reveals the Genes Responsible for Pheromonal Communication Among Rodents

Research among the first published analyses of Celera mouse genome database Rockefeller University scientists report that the way mice communicate with each other is far more complex -- and has a more elaborate evolutionary history -- than imagined. The research, published in the February issue o...
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Another Transmembrane Protein Structure Solved by Rockefeller Scientists

Chloride Ion Channel Strikingly Different from Potassium Kin "Why did nature come up with such a structural plan?" ask Rockefeller University professor Roderick MacKinnon and colleagues in their Jan. 17 Nature cover article describing the three-dimensional structure of a type of chloride channe...
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Malignant Cells Survive-and Replicate-Because Cancer-causing Molecule Jams Normal p53 Cell-suicide Trigger

Rockefeller Researchers Uncover Clue to Improving Cancer Chemotherapy A cancer-causing molecule called WISP-1 may explain why some people with cancer do not benefit from chemotherapy while others with the same form of cancer respond to the treatment, according to researchers at The Rockefeller Un...
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Novel Method To Fight Drug-resistant Infections Emerges from Lab - and Nature

Bacteria's natural foe may prove valuable human friend Scientists have turned to nature once again for help in fighting deadly infections. Reporting in the Dec. 7 issue of Science, Rockefeller University researchers show that a natural enzyme derived from tiny viruses that live inside bacteria...
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Researchers Uncover Molecular Basis of Second Leading Cause of Mental Retardation

Protein implicated in fragile X syndrome in charge of crucial brain cell events Scientists at last may have determined how mental retardation develops in people with fragile X syndrome, a condition caused by the inherited loss of an essential protein, termed the fragile X mental retardation prote...

M.D.-Ph.D. Training Program for Minority Students Receives $500,000 Grant

The Andrew W. Mellon Foundation has pledged a $500,000 challenge grant over the next three years to help create a $1 million endowment for the Gateways to the Laboratory Program. Gateways is a 10-week summer training program that enables talented freshman and sophomore college students from minor...
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Rockefeller Researchers Discover Possible Trigger for "Killer T Cells" To Attack

New study indicates how the body may come to turn against itself How do "killer T cells" know when to attack virus-infected and cancerous cells, and when to retreat? The answer possibly has been provided by Rockefeller University research to be published in the Nov. issue ofNature Immunology, and...
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