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Found 37173 matches. Displaying 4921-4930
Zhu XD, Girardo D, Govek EE, John K, Mellen M, Tamayo P, Mesirov JP, Hatten ME
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Role of Tet1/3 Genes and Chromatin Remodeling Genes in Cerebellar Circuit Formation
NEURON 2016 JAN 6; 89(1):100-112
Although mechanisms underlying early steps in cerebellar development are known, evidence is lacking on genetic and epigenetic changes during the establishment of the synaptic circuitry. Using metagene analysis, we report pivotal changes in multiple reactomes of epigenetic pathway genes in cerebellar granule cells (GCs) during circuit formation. During this stage, Tet genes are upregulated and vitamin C activation of Tet enzymes increases the levels of 5-hydroxymethylcytosine (5hmC) at exon start sites of upregulated genes, notably axon guidance genes and ion channel genes. Knockdown of Tet1 and Tet3 by RNAi in ex vivo cerebellar slice cultures inhibits dendritic arborization of developing GCs, a critical step in circuit formation. These findings demonstrate a role for Tet genes and chromatin remodeling genes in the formation of cerebellar circuitry.
Keller A
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The distinction between perception and judgment, if there is one, is not clear and intuitive
BEHAVIORAL AND BRAIN SCIENCES 2016; 39(?):? Article e249
Thi VLD, Debing Y, Wu XF, Rice CM, Neyts J, Moradpour D, Gouttenoire J
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Sofosbuvir Inhibits Hepatitis E Virus Replication In Vitro and Results in an Additive Effect When Combined With Ribavirin
GASTROENTEROLOGY 2016 JAN; 150(1):82-85
Infection with hepatitis E virus genotype 3 may result in chronic hepatitis in immunocompromised patients. Reduction of immunosuppression or treatment with ribavirin or pegylated interferon-alpha can result in viral clearance. However, safer and more effective treatment options are needed. Here, we show that sofosbuvir inhibits the replication of hepatitis E virus genotype 3 both in subgenomic replicon systems as well as a full-length infectious clone. Moreover, the combination of sofosbuvir and ribavirin results in an additive antiviral effect. Sofosbuvir may be considered as an add-on therapy to ribavirin for the treatment of chronic hepatitis E in immunocompromised patients.
Catto S, Kheyfits A, Tepper DE
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M. Riesz Theorem on Conjugate Harmonic Functions for Octonion-Valued Monogenic Functions
XXIII INTERNATIONAL CONFERENCE ON INTEGRABLE SYSTEMS AND QUANTUM SYMMETRIES (ISQS-23) 2016; 670(?):? Article UNSP 012017
The classical theorem of M. Riesz about the conjugate harmonic functions is extended onto octonion-valued monogenic functions.
Pettit P
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A Brief History of Liberty-And Its Lessons
JOURNAL OF HUMAN DEVELOPMENT AND CAPABILITIES 2016 JAN 2; 17(1):5-21
Classical republicanism and classical liberalism divide on the understanding of freedom, the one taking it as non-domination, the other as non-interference. And essentially the same division survives today, with serious policy implications, between neo-republicanism and neo-liberalism.
Fins JJ
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In Remembrance, with Thanks to Voltaire
CAMBRIDGE QUARTERLY OF HEALTHCARE ETHICS 2016 JAN; 25(1):107-109
Keller A
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Is conscious content available only to the skeletal muscle system?
BEHAVIORAL AND BRAIN SCIENCES 2016; 39(?):? Article e183
I applaud Morsella et al.'s approach to investigate consciousness in terms of behavioral control. After all, the function of the brain is to control behavior, and consciousness contributes to the function of the brain. However, I question whether conscious content is available only to the skeletal muscle system, as the principle of parallel responses into skeletal muscle (PRISM) (Morsella 2005) proposes.
Sun JC, Yuan ZN, Georgescu R, Li HL, O'Donnell M
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The eukaryotic CMG helicase pumpjack and integration into the replisome
NUCLEUS 2016; 7(2):146-154
The eukaryotic replisome is a multiprotein machine that contains DNA polymerases, sliding clamps, helicase, and primase along with several factors that participate in cell cycle and checkpoint control. The detailed structure of the 11-subunit CMG helicase (Cdc45/Mcm2-7/GINS) has been solved recently by cryoEM single-particle 3D reconstruction and reveals pumpjack motions that imply an unexpected mechanism of DNA translocation. CMG is also the organizing center of the replisome. Recent in vitro reconstitution of leading and lagging strand DNA synthesis has enabled structural analysis of the replisome. By building the replisome in stages from pure proteins, single-particle EM studies have identified the overall architecture of the eukaryotic replisome. Suprisingly leading and lagging strand polymerases bind to opposite faces of the CMG helicase, unlike the long-held view that DNA polymerases are located in back of the helicase to act on the unwound strands.
Kim J, Oh CH, Jeon J, Baek Y, Ahn J, Kim DJ, Lee HS, da Rosa JC, Suarez-Farinas M, Lowes MA, Krueger JG
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Molecular Phenotyping Small (Asian) versus Large (Western) Plaque Psoriasis Shows Common Activation of IL-17 Pathway Genes but Different Regulatory Gene Sets
JOURNAL OF INVESTIGATIVE DERMATOLOGY 2016 JAN; 136(1):161-172
Psoriasis is present in all racial groups, but in varying frequencies and severity. Considering that small plaque psoriasis is specific to the Asian population and severe psoriasis is more predominant in the Western population, we defined Asian small and intermediate plaque psoriasis as psoriasis subtypes and compared their molecular signatures with the classic subtype of Western large plaque psoriasis. Two different characteristics of psoriatic spreading-vertical growth and radial expansion-were contrasted between subtypes, and genomic data were correlated to histologic and clinical measurements. Compared with Western large plaque psoriasis, Asian small plaque psoriasis revealed limited psoriasis spreading, but IL-17A and IL-17-regulated proinflammatory cytokines were highly expressed. Paradoxically, IL-17A and IL-17-regulated proinflammatory cytokines were lower in Western large plaque psoriasis, whereas T cells and dendritic cells in total psoriatic skin area were exponentially increased. Negative immune regulators, such as CD69 and FAS, were decreased in both Western large plaque psoriasis and psoriasis with accompanying arthritis or obesity, and their expression was correlated with psoriasis severity index. Based on the disease subtype comparisons, we propose that dysregulation of T-cell expansion enabled by downregulation of immune negative regulators is the main mechanism for development of large plaque psoriasis subtypes.
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A search for pair production of new light bosons decaying into muons
PHYSICS LETTERS B 2016 JAN 10; 752(?):146-168
A search for the pair production of new light bosons, each decaying into a pair of muons, is performed with the CMS experiment at the LHC, using a dataset corresponding to an integrated luminosity of 20.7 fb(-1) collected in proton-proton collisions at center-of-mass energy of root s = 8 TeV. No excess is observed in the data relative to standard model background expectation and a model independent upper limit on the product of the cross section, branching fraction, and acceptance is derived. The results are compared with two benchmark models, the first one in the context of the next-to-minimal super-symmetric standard model, and the second one in scenarios containing a hidden sector, including those predicting a nonnegligible light boson lifetime. (C) 2015 CERN for the benefit of the CMS Collaboration. Published by Elsevier B.V.