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Noninfectious versions of SARS-CoV-2 provide powerful research tools

The new experimental system will facilitate efforts to study different coronavirus variants and develop new drugs for
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  • Small molecule may prevent metastasis in colorectal cancer

    The compound works by hindering a key pathway that cancer cells rely upon to hoard energy, and is already undergoing clinical trials.


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    Novel method for trapping HIV inside its host may give rise to new antivirals

    Human cells can be coaxed into preventing certain enveloped viruses (including HIV, Ebola, and parainfluenza) from escaping their membranes in the lab, a finding that could lead to novel treatments for many viral diseases.

    Could future coronavirus variants fully dodge our immune system?

    Studying dozens of naturally occurring and laboratory-selected mutations in SARS-CoV-2, researchers found that the virus will need to pull off a genetic feat to become fully resistant to antibodies.

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    Missing immune molecule may explain why some HPV patients sprout giant horn-like growths

    Scientists identified a mutation that affects one’s reaction to HPV by decreasing the production of CD28, a vital molecule within the immune system.

    Natural infection versus vaccination: Differences in COVID antibody responses emerge

    People who recover from COVID-19 may have better protection than those who received a vaccine, but the benefits of natural immunity do not outweigh the very real risk of disability and death from contracting the disease.

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    The common thread in severe COVID-19 

    New studies point to a single molecular explanation for 20 percent of critical COVID-19 cases: insufficient or defective type I interferons.

    Hunting for TB's most vulnerable genes

    Not every gene that's essential in tuberculosis is also vulnerable to attack. A new study ranks essential genes by vulnerability, allowing researchers to better prioritize future drug targets.

    Putting the brakes on immune reactions

    Helper T cells may play a dual role in the immune system, both encouraging and suppressing the process by which B cells mature.

    How CRISPR promotes antibiotic resistance in bacteria

    Whenever a cell uses CRISPR to defend itself, there's a chance of mutations creeping into its genetic code. Some of these mutations are harmless; others kill the cell. But fortuitous mutations can occasionally render major human pathogens, such as Staphylococcus aureus, antibiotic resistant.