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Displaying 62 of 2916 articles.
A new class of antivirals could help prevent future pandemics
The arrival of Paxlovid in December 2021 marked another turning point in the COVID-19 pandemic—an effective antiviral that has since successfully treated millions. But like many antivirals before it, scientists know that at some point, Paxlovid is likely to lose some efficacy due to drug r...
Could a bout of COVID protect you from a severe case of flu?
...By analyzing mice that had been first infected with SARS-CoV-2 and then with influenza A virus, the scientists found that having recovered from COVID had a protective effect against the worst effects of the flu, and that this memory response was coming from an unexpected corner of the i...
West Nile infections are spiking. Here’s why the percentage of severe cases is so small
...Interestingly, it isn’t the first time they’ve uncovered a link between severe symptoms and the presence of these autoantibodies; they’ve previously documented the phenomenon in cases of severe COVID and flu pneumonia. We spoke to Casanova, a researcher with the university’s Stavros Nia...
Surprising reason that B cells benefit from booster shots
Certain infectious diseases, such as COVID or the flu, evolve constantly, shapeshifting just enough to outmaneuver our immune systems and reinfect us repeatedly. But subsequent reinfections often don’t lead to the most severe outcomes—for very good reason. Upon first exposure to a pathogen...
Innovative approach opens the door to COVID nanobody therapies
COVID is not yet under control. Despite a bevy of vaccines, monoclonal antibodies, and antivirals, the virus continues to mutate and elude us. One solution that scientists have been exploring since the early days of the pandemic may come in the form of tiny antibodies derived from llamas, ...
An immune flaw may cause West Nile virus’s deadliest symptoms
...West Nile virus now joins a small but important group of infectious diseases with a documented link between interferon-neutralizing autoantibodies and cases resulting in the most severe or deadly symptoms, including influenza (5%), COVID (15%), and MERS pneumonia (25%). But with 40% of ...
Boosters are key to protecting pregnant individuals and newborns against the worst effects of COVID
...But how long does this protection last? A new study from The Rockefeller University and Weill Cornell Medicine (WCM), published in Nature Communications, found that patients with a specific cocktail of COVID exposure—vaccination, up-to-date boosters, and previous infection—had the highe...
How antibodies from llamas may lead to COVID-19 treatment
...Nanobodies could become one more weapon in our arsenal against COVID-19, and potentially a widely available one.” In order to get there, Rout, Chait and their colleagues are now extracting antibodies from llamas and examining their molecular properties to identify those most effective a...
As COVID-19 vaccines emerge, the search for antiviral drugs continues
Highly promising vaccines have recently emerged for COVID-19, but this doesn’t mean research into other treatments can slow down. There is still no cure for the disease, and people will likely continue to get sick even after vaccines become widely available—by not getting their COVID
What we need to worry about with avian flu—and what we don’t 
...You’d hope after the COVID pandemic that there’d be much more surveillance and screening. Instead, we have significant gaps in information. However, scientists are doing whatever they can. They’ve analyzed the sequence of the virus and calculated when this flu jumped from birds into cow...
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