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"Genome destroyer" identified in the immune system

Enzyme called AID is the initial culprit in B cell cancers Our bodies have such great capacity to heal, it's hard to imagine that we naturally manufacture a product in our immune system that can endanger our own DNA and provide a biological footstep to cancer. But this is precisely the case. In t...
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Hormone replacement therapy one hour at a time

Rodent study suggests approach to keep good and lose bad effects of standard hormone treatments Giving hormone doses in pulses, rather than as a steady exposure, may maximize the benefits and limit the side effects now associated with hormone therapies. This is one implication of the findings sci...
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Viral locksmith is caught in the act

Interactions between viral and bacterial proteins promise new directions for antibiotics How does the molecular machine responsible for activating genes choose which gene to switch on, from among the 30,000 genes contained in each cell of the human body? In the August 4 issue of the EMBO Journa...
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Through population screening on the island of Kosrae, Rockefeller scientists discover a mutant gene that controls dietary cholesterol absorption

Findings may contribute to revealing genetic underpinnings of high cholesterol Using DNA from 1,000 inhabitants of the Micronesian island of Kosrae, Rockefeller University scientists have discovered a mutant gene that affects an individual's absorption of dietary cholesterol. The findings are rep...
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Preparing for a safe split

Rockefeller scientists show how cells establish the correct line-up of chromosomes before they divide As it prepares to divide, a human cell makes exact copies of all of its 46 chromosomes, so that the two daughter cells each can have a complete set of genetic material. The two sets must separate...
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Activation of tumor suppressor gene p53 much more complex than previously believed

It's the biochemist's twist on the old light bulb jokes: how many proteins does it take to activate a gene? Scientists in Robert Roeder's Laboratory of Molecular Biology and Biochemistry at Rockefeller University now know that, at least for gene activation by the tumor suppressor p53, the answer ...
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Lab mice rescued from Type 1 diabetes via dendritic cell-assisted therapy

Research reveals impending autoimmunity can be stopped Rockefeller University researchers have for the first time demonstrated a halting of early Type 1 diabetes in mice by restoring a critical class of T cells to their normal balance. The findings, reported in the June 7 issue of theJournal of ...
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Cell growth and death controlled by a single pathway in lymphoma cancer model

Researchers provide first molecular description of a cancer caused by bacteria New research at Rockefeller University, published this week in the online edition of the Proceedings of the National Academy of Sciences, helps explain why some people do not respond to chemotherapy and offers a possib...
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Molecular image of genotoxin reveal how bacteria damage human DNA

The three-dimensional structure of a DNA-damaging, bacterial toxin has been visualized by scientists at Rockefeller University. The molecular image of the toxin, published in the May 27 issue of the journalNature, shows exactly how the toxin is put together at the molecular level and damages huma...
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Newly discovered gene controls levels of "bad" cholesterol in mice

Heart disease researchers at Rockefeller University have discovered the function of a gene associated with high cholesterol levels in humans. Using mice as test subjects, the Rockefeller scientists determined that the gene, called Pcsk9, can decrease the number of receptors on liver cells that re...
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