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Rockefeller University Researchers Find Large Hole-Forming Protein in Bacteria -- A Potential Achilles' Heel?

Finding Opens Door on Dysentery, Bubonic Plague, Cholera and Salmonella Poisoning Researchers at The Rockefeller University have shown for the first time that a protein called pIV forms a hole in the outer membrane of the bacterium E. coli to allow passage of large molecules. The finding, reporte...
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Neurobiologists Show How the Brain Processes Signals from Pheromones

Researchers at The Rockefeller University have shown for the first time in mice how the brain processes signals from pheromones, essential chemicals used by animals to communicate with each other. Reported in the April 16 issue of Cell, the findings provide the first look at the "wiring diagram" ...
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Researchers Shed Light on How Cells Commit Suicide

A team of researchers led by Associate Professor David Cowburn, Ph.D., has determined the three-dimensional structure of a molecule that regulates programmed cell death, a critical process important for many diseases, including cancer, heart disease and autoimmunity. The structure, reported in th...
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Researchers Report Emergence of Antibiotic Resistance during Vancomycin Therapy

Antibiotic Combination Shown To Be Effective against Resistant Bug A team of researchers led by The Rockefeller University's Alexander Tomasz, Ph.D., have described the case of a 79-year-old patient whose death in a New York metropolitan area hospital last March was associated with a bloodstream ...
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A Little Stress May Have Big Benefits for Health

Rockefeller University Researchers Show That Acute Stress Sends Early Warning Signal to Immune System Rockefeller University researchers have shown that brain hormones rally immune cells in response to stress. The findings, reported in the Feb. 2 issue of the Proceedings of the National Academy o...
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Scientists Show That Normal-looking Cells in Cervical Cancer May Be Abnormal

Findings may broaden definition of cancer, leading to improved diagnostics and treatments Researchers from The Rockefeller University and Digilab, using a technique called infrared (IR) spectroscopy, have shown that normal-looking cells taken from women with cervical cancer may actually be abnorm...
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Scientists Show for the First Time How Leprosy Bug Targets Peripheral Nerves

A team of researchers, led by scientists from The Rockefeller University, have identified how the bacterium that causes leprosy targets the peripheral nerve, the crucial step leading to nerve damage in this disease. The findings, reported in the Dec. 11 issue of the journal Science, open a window...
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Rockefeller Researchers Show First Evidence for Naturally Occurring Tumor Immunity in Humans

For a small percentage of the population, it is known that the body's immune system can successfully mount an attack against their tumors, often without the person even knowing that a tumor exists. But this victory comes at a price, for the body then turns against itself and attacks brain cells, ...
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Structure of Enzyme Involved in Gentamicin Resistance Revealed for First Time

A team of scientists, led by researchers from the Howard Hughes Medical Institute (HHMI) at The Rockefeller University, has determined the three-dimensional structure of an enzyme responsible for resistance of certain bacteria to the antibiotic gentamicin. The structure, reported in the August 21...
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Subtle Changes in Brain Receptor Gene May Have Significant Consequences for Addiction

Scientists have identified five slightly different versions of the mu opioid receptor gene that alter the activity of a molecule called b-endorphin, a member of the endorphin family of proteins that can numb pain, create feelings of euphoria or increase energy, which opiates and other drugs of an...
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