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Displaying 62 of 2916 articles.
This technique for studying cell receptors could have sweeping implications for drug development
...While this work is the culmination of a team effort over a long period of time, Kotliar made herculean efforts to drag it across the finish line—shuttling samples and scarce reagents back and forth from Sweden in rare travel windows during COVID. It paid off. The results provide a handf...
Homing in on the genetics of severe COVID in children
One of the most terrifying aspects of the COVID pandemic has been its unpredictably severe impact on some children. While most infected kids have few or no symptoms, one in 10,000 fall suddenly and dramatically ill about a month after a mild infection, landing in the hospital with inflamed...
How antibody therapy impacts COVID vaccines
...The findings suggest that feedback inhibition increases the coverage provided by COVID vaccines in people who previously received monoclonal antibodies. "Depending on the virus, feedback inhibition can either enhance immunity or inhibit it," says Michel C. Nussenzweig, who co-led the st...
Common mutation linked to COVID mortality
It may be the most baffling quirk of COVID: What manifests as minor, flu-like symptoms in some individuals spirals into severe disease, disability, or even death in others. New research published in Nature may explain the genetic underpinnings of this dichotomy.  The researchers demonstrat...
Amid the rush for COVID-19 drugs, a case for the helicase
...Around the world, researchers working on developing treatments for COVID-19 are intensively examining each step of this process. Among them is Rockefeller’s Pels Family Professor Tarun Kapoor, whose lab has turned its expertise on stopping propagation of cancer cells to the virus, focus...
The common thread in severe COVID-19 
Patients who suffer from severe COVID-19 tend to have one thing in common: insufficient or defective proteins that help regulate the immune system, known as type I interferons (IFNs).   Two papers from the laboratory of Jean-Laurent Casanova previously demonstrated that at least 10 percent...
New design may boost potency of monoclonal antibodies against COVID
Monoclonal antibody drugs are among the few treatments available for COVID, providing a lifeline for those at high risk of severe illness and hospitalization. However, the usefulness of these drugs is limited because they are effective only when they can be administered early in the diseas...
Rogue enzymes cause numerous diseases. A new method could help design drugs to treat them.
...The paper, published in the Journal of the American Chemical Society, describes how researchers used this innovative new platform to design molecules that take aim at helicases involved in COVID and certain cancers. "High-resolution structural and biochemical data alone are not sufficie...
Waddling water bears, grandmother neurons, and other memorable science stories of 2021
...Basic biomedical research went on, unabated, through the second year of New York City's touch-and-go battle with COVID. Investigations into the nature of the novel coronavirus and its intractable variants intensified, demanding the attention of more than 25 Rockefeller laboratories, all...
Intriguing science discoveries of 2022
For the past three years, the COVID pandemic altered virtually every aspect of our lives. But we’ve been in a transitional phase in 2022, shifting towards the new normal. Science at Rockefeller has been in transition, too. Deeper insights into the nuances of COVID infection emerged,...
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