Scientists have found that many receptors with high potential for drug discovery take a different configuration inside the body than in the test tube. The findings could explain why some promising drugs fail in clinical trials, and potentially open doors to new drug-development approaches.
Using a new technique to study brain development, scientists were able to trace the causes of Huntington's back to early developmental stages when the brain has only just begun to form.
A common birthplace of new genes, the male testes are a hotspot for biological innovation. Within these organs, scientists have found a trove of virgin genetic sequences—and a better understanding of how evolution moves forward.
Researchers have shown that antibodies against Zika might be involved in causing birth defects in babies born to infected women. The findings might provide important caveats for the development of a vaccine.
Cell division is critical to creating and sustaining life. It’s also incredibly difficult to study. Now, advanced technology is enabling researchers to take their understanding of this process to the next level.
For the brain to function smoothly, its cells must carefully regulate which proteins are produced and when. By studying gene regulation, researchers are now shedding light on complex brain conditions like autism and stroke.
Navigating fruit flies do not have the luxury of GPS, but they do have a kind of neural compass. In a new study, researchers found that the animals decide which way to turn by comparing this internal compass needle to a fixed goal.
Drugs known as potentiators alleviate some symptoms of cystic fibrosis. Researchers recently figured out how these compounds work—a finding that may lead to better drugs that patients can more easily afford.
Researchers have created a new 3D model of human embryonic tissue that promises to shed light on critical components of development—including processes that go awry during pregnancy complications.
Scientists have found a group of brain cells that influence body mass in two ways, by controlling how much we eat as well as how much energy we burn. The findings could lead to new drugs to help people shed weight.
