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The rockefeller university

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Displaying 62 of 2939 articles.
Rogue enzymes cause numerous diseases. A new method could help design drugs to treat them.
...The paper, published in the Journal of the American Chemical Society, describes how researchers used this innovative new platform to design molecules that take aim at helicases involved in COVID and certain cancers. "High-resolution structural and biochemical data alone are not sufficie...
Intriguing science discoveries of 2022
For the past three years, the COVID pandemic altered virtually every aspect of our lives. But we’ve been in a transitional phase in 2022, shifting towards the new normal. Science at Rockefeller has been in transition, too. Deeper insights into the nuances of COVID infection emerged,...
A third vaccine dose may increase protection from Omicron
The mRNA vaccines used against COVID were never designed to battle the Omicron variant, a now dominant strain of the coronavirus that recently claimed 18,000 lives in a single week. Yet individuals who receive their third dose appear to be protected from the worst of Omicron, and a new stu...
Llama antibodies could help fight SARS-CoV-2 variants
Amid the growing threat of a new and potentially more dangerous SARS-CoV-2 variant, scientists are ramping up the quest for COVID treatments. A recent study demonstrates the therapeutic potential of an unusual class of immune proteins: miniature antibodies called nanobodies, derived from l...
Lonely flies, like many humans, eat more and sleep less
COVID-19 lockdowns scrambled sleep schedules and stretched waistlines. One culprit may be social isolation itself. Scientists have found that lone fruit flies quarantined in test tubes sleep too little and eat too much after only about one week of social isolation, according to a new study...
COVID-19 immunology study reveals universally effective antibodies
...A study of 149 people who have recovered from COVID-19 shows that although the amount of antibodies they generated varies widely, most individuals had generated at least some that were intrinsically capable of neutralizing the SARS-CoV-2 virus. The findings are published June 18 in the ...
Rockefeller saliva test for COVID-19 outperforms commercial swab tests
In the early days of the pandemic, with commercial COVID tests in short supply, Rockefeller’s Robert B. Darnell developed an in-house assay to identify positive cases within the Rockefeller community. It turned out to be easier and safer to administer than the tests available at the time, ...
Intriguing science discoveries of 2023
...Efforts to combat COVID, Hepatitis B, and other infections bore fruit, and countless papers shed light on basic research, answering questions that have long baffled biologists. Here are some of the intriguing discoveries that came out of Rockefeller in 2023. Old sperm, new mutations As ...
Natural infection versus vaccination: Differences in COVID antibody responses emerge
...Hope for a future without fear of COVID-19 comes down to circulating antibodies and memory B cells. Unlike circulating antibodies, which peak soon after vaccination or infection only to fade a few months later, memory B cells can stick around to prevent severe disease for decades. And t...
COVID-19 vaccines may need regular updates for emerging variants
...Soon after the world’s first COVID-19 vaccination campaigns kicked off, news emerged about new, more contagious SARS-CoV-2 variants crisscrossing the planet. The discovery of such strains in Britain, Brazil, and South Africa has raised a pressing concern: Will current vaccines be effect...
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