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First structural map of the cystic fibrosis protein sheds light on how mutations cause disease

Rockefeller scientists have created the first three-dimensional map of the protein responsible for cystic fibrosis, an inherited disease for which there is no cure. This achievement, described December 1 in Cell, offers the kinds of insights essential to better understanding and treating this oft...
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Survey of New York City soil uncovers medicine-making microbes

Microbes have long been an invaluable source of new drugs. And to find more, we may have to look no further than the ground beneath our feet. Researchers at The Rockefeller University have shown that the dirt beneath New York City teems with our tiny allies in the fight against disease. In soil c...
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New research clarifies why wounds heal more slowly with age

Older bodies need longer to mend. This reality of aging has been documented since World War I, with the observation that wounds heal slower in older soldiers. Yet until now, researchers have not been able to tease out what age-related changes hinder the body’s ability to repair itself. Recent e...
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Researchers discover new antibiotics by sifting through the human microbiome

Most antibiotics in use today are based on natural molecules produced by bacteria—and given the rise of antibiotic resistance, there’s an urgent need to find more of them. Yet coaxing bacteria to produce new antibiotics is a tricky proposition. Most bacteria won’t grow in the lab. And even whe...
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Researchers shed new light on RNA’s journey out of a cell’s nucleus

Cells secure DNA within their nuclei like a secret code stashed in a vault. However, the tightly controlled borders of the nucleus create a challenge: In order for the cell to produce essential proteins, messages derived from DNA must somehow escape the nucleus in the form of RNA molecules. New w...
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Scientists prove how genetics change behavior by studying worms’ foraging strategies

“Organisms pay attention to what other members of their species are doing,” says Cori Bargmann, a neuroscientist at Rockefeller University. “It’s a very robust phenomenon that you see from humans on Twitter to bacteria, and everything in between.” That’s why Bargmann, Torsten N. W...
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Researchers watch in 3D as neurons talk to each other in a living mouse brain

No single neuron produces a thought or a behavior; anything the brain accomplishes is a vast collaborative effort between cells. When at work, neurons talk rapidly to one another, forming networks as they communicate. Researchers led by Rockefeller University’s Alipasha Vaziri are developing tech...
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Genomic testing could speed research on skin disease and bring new drugs to patients faster

In an ideal world, the newest and most effective drugs for chronic inflammatory conditions would immediately help everyone who took them. Unfortunately, in the real world, it can take several months to determine whether a given patient will respond to one of these medications, which target specif...
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Study uncovers how cells organize the growth of their structural filaments

To take shape, to move and to reproduce, cells need internal scaffolding composed of slender filaments known as microtubules. Before the cell can use microtubules for these and other essential functions, it must first organize them into carefully crafted bundles, which become the basis for three ...
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A possible explanation for why male mice tolerate stress better than females

The nerves we feel before a stressful event—like speaking in public, for example—are normally kept in check by a complex system of circuits in our brain. Now, scientists at Rockefeller University have identified a key molecule within this circuitry that is responsible for relieving anxiety. Intr...
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