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The rockefeller university

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Displaying 62 of 2916 articles.
Lab-grown mini lungs could accelerate the study of respiratory diseases  
...Our understanding of how infectious diseases like COVID affect human lungs has been similarly confounded by noise. Data from patient lung tissues greatly varies from person to person, obscuring the basic mechanisms of how, exactly, SARS-Co-V2 first infects lung cells. It’s also an after...
"Exhausted" immune cells may drive Alzheimer's
...Prior work from the Tavazoie lab has demonstrated that these variants can play pivotal roles in how the body responds to diseases from cancer to COVID, but the link between Alzheimer's disease and APOE4 is particularly well-established: the APOE4 variant, carried by about 20 percent of ...
Study of “breakthrough” cases suggests COVID testing may be here to stay
In rare cases, people who have been fully vaccinated against COVID and are immune to the virus can nevertheless develop the disease. New findings from The Rockefeller University now suggest that these so-called breakthrough cases may be driven by rapid evolution of the virus, and that ongo...
A unique window into "original antigenic sin"
...Scientists call this original antigenic sin (OAS)—the body's first blush with a virus like influenza or COVID being the "original sin" that forever biases its immune response against newer strains. According to the OAS theory, no matter how many flu vaccines or COVID boosters we ...
Rockefeller begins testing of new COVID-19 antibody drug in people
With green light from the FDA, Rockefeller scientists started human trials this week for a new monoclonal antibody drug as a potential treatment for COVID-19. Monoclonal antibodies are mass-produced replicas of natural antibodies made by the immune system to fight viruses. Designed to prev...
Rockefeller scientists launch a broad range of studies into novel coronavirus
Rockefeller University experts in infectious disease, immunology, biochemistry, structural biology, and genetics have begun over a dozen projects in recent weeks aimed at better understanding the biology of the SARS-CoV-2 virus, which is responsible for the current global COVID-19 pandemic...
Rockefeller scientists investigate life-threatening inflammation affecting children with COVID-19
...As part of an international study of genetic causes behind severe COVID-19 in young people, Casanova and collaborators have been enrolling these unusual cases since early March, when they were first reported by European doctors. Collaborating with the New York Genome Center and the stat...
What bats can teach us about COVID-19
...But at the outset of the COVID-19 pandemic, he diverted his expertise and applied the same methods to instead to see if they could crack the mystery of bats’ exceptional immunity to coronavirus. His group began by sequencing the genome of the horseshoe bat, thought to be the initial hos...
The immune system mounts a lasting defense after recovery from COVID-19
As the number of people who have fought off SARS-CoV-2 climbs ever higher, a critical question has grown in importance: How long will their immunity to the novel coronavirus last? A new Rockefeller study offers an encouraging answer, suggesting that those who recover from COVID-19 are prot...
Rockefeller grants commercial license for the development of monoclonal antibodies for treatment of COVID-19
With promising results from preclinical studies and with human trials now underway, Rockefeller has taken the next step with its novel COVID-19 treatment. The university has entered a licensing agreement with a global pharmaceutical company to advance development of a drug based on two mon...
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