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Science News

Analysis of sperm differentiation reveals new mode of proteasome regulation

Early in development, cells undergo a controlled demolition that helps to shape their raw, pliable material into the specialized forms they must have to do their jobs as adults. The process by which this occurs is also crucial later in the cell’s life, to take out potentially dangerous trash that...
Science News

Anti-inflammatory drugs reduce effectiveness of SSRI antidepressants

Scientists at Rockefeller University have shown that anti-inflammatory drugs, which include ibuprofen, aspirin and naproxen, reduce the effectiveness of the most widely used class of antidepressant medications, the selective serotonin reuptake inhibitors, or SSRIs, often prescribed for depression...
Science News

Polarized microscopy technique shows new details of how proteins are arranged

Whether you’re talking about genes, or neurons, or the workings of a virus, at the most fundamental level, biology is a matter of proteins. So understanding what protein complexes look like and how they operate is the key to figuring out what makes cells tick. By harnessing the unique properties ...
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'Big picture' of how interferon-induced genes launch antiviral defenses revealed

When viruses attack, one molecule more than any other fights back. Interferon triggers the activation of more than 350 genes, and despite the obvious connection, the vast majority have never been tested for antiviral properties. A team of researchers, led by scientists from Rockefeller University...
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Researchers put potent staph killer to the test, hope for new drug treatment

Standard antibiotics, and even those reserved for the most defiant infections, are fighting an uphill battle against the evolutionary ingenuity of bacterial defenses. Staphylococci, and especially methicillin-resistant Staphylococcus aureus (MRSA), is a particular scourge in hospitals, and is inc...
Science News

Bullying alters brain chemistry, leads to anxiety

Being low mouse on the totem pole is tough on murine self-esteem. It turns out it has measurable effects on brain chemistry, too, according to recent experiments at Rockefeller University. Researchers found that mice that were bullied persistently by dominant males grew unusually nervous around n...
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University receives accreditation for its human research protection program

The Rockefeller University has received accreditation from The Association for the Accreditation of Human Research Protection Programs, Inc. (AAHRPP), a program that recognizes research organizations’ commitments to providing strong safeguards on behalf of human research participants. Considered ...
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Molecule that spurs cell’s recycling center may help Alzheimer’s patients

Cells, which employ a process called autophagy to clean up and reuse protein debris leftover from biological processes, were the original recyclers. A team of scientists from Paul Greengard’s Rockefeller University laboratory have linked a molecule that stimulates autophagy with the reduction of ...
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New genetic technique probes the cause of skin cell differentiation in mammals

A tremendous amount of genetics research has been done in flies and tiny worms, in part because scientists have good tools for tweaking these creatures’ DNA. Now, by adapting a powerful method of RNA interference for use in mice, researchers have identified key pathways that cause skin cells to d...
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‘Round-the-clock’ lifestyle could disrupt metabolism, brain and behavior

In Civilization and Its Discontents, Sigmund Freud argued that modern society was hard on human psychology, forcing people to get along in unnaturally close quarters. Now newly published research from The Rockefeller University points out a different discontent in the developed world, namely, the...
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