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Science News

New HIV vaccine trial first to target dendritic cells

When HIV was first discovered to cause AIDS in 1981, prominent scientists expected to have an effective vaccine within a couple of years. Three decades later, the disease has killed more than 25 million people and defied every effort so far to inoculate against it. But researchers at Rockefeller ...
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New research shows how experience shapes the brain’s circuitry

Neuroscientists once thought that the brain’s wiring was fixed early in life, during a critical period beyond which changes were impossible. Recent discoveries have challenged that view, and now, research by scientists at Rockefeller University suggests that circuits in the adult brain are con...
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Problematic blood clotting contributes to Alzheimer’s disease

Alzheimer’s disease has long been studied primarily as a disease of neurons. But researchers have now shown how the disease may be damaging the brain by choking off blood flow. In experiments published June 10 in Neuron, scientists at Rockefeller University reveal that amyloid-β, which builds up ...
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Alzheimer’s brain protein may provide target for treating mental retardation

From the perspective of neuroscientists, Alzheimer’s disease and Down syndrome have at least one thing in common: patients with both diseases have an accumulation of β-amyloid protein in their brains. Rockefeller University scientists now provide evidence that drugs which help reduce the leve...
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Researchers modify yellow fever vaccine to fight malaria

There is no vaccine for malaria, which sickens almost a quarter of a billion people each year and kills a child every 30 seconds. That could be changing: researchers at The Rockefeller University have genetically transformed the yellow fever vaccine to prime the immune system to fend off the mos...
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New study of psoriatic cells could fire up the study of inflammation

New research promises to pry some long held secrets from one of humanity’s oldest known diseases. Scientists at Rockefeller University have discovered how to parse the most troublesome cells behind the debilitating skin lesions in psoriasis and have identified several distinctive markers that ...
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Scientists identify potential new target for schizophrenia drugs

Rockefeller University scientists have identified a protein that boosts the signaling power of a receptor involved in relaying messages between brain cells, a finding that suggests a new target for the development of treatments for schizophrenia and Parkinson’s disease. The protein, called Nor...
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Cell division orchestrated by multiple oscillating proteins, new research finds

Cell division is a crucial but dangerous business. It unfolds in a cycle of many steps, including DNA replication, spindle formation, mitosis and others, and they must happen in the right order to prevent abnormal cell death and cancer formation. New research from Rockefeller University examines...
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New gene for hair loss identified

A newly identified gene connected to hair growth may inform future treatments for male pattern baldness, says a team of researchers from Rockefeller, Columbia and Stanford Universities. The scientists found that the gene, called APCDD1, causes a type of progressive hair loss known as hereditary ...
Science News

New probe technology illuminates the activation of light-sensing cells

Ultimately, Charles Darwin’s “endless forms most beautiful and most wonderful” can be boiled down to a scant 20 or so amino acids, the basic building blocks of life. From this parsimonious palette, nature paints the proteins that make up the wild diversity of life on earth, from the simple...
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