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New antibiotic beats superbugs at their own game

The problem with antibiotics is that, eventually, bacteria outsmart them and become resistant. But by targeting the gene that confers such resistance, a new drug may be able to finally outwit them. Rockefeller University scientists tested the new drug, called Ceftobiprole, against some of the dea...

Newly identified enzyme treats deadly bacterial infection in mice

By the time antibiotics made their clinical debut 70 years ago, bacteria had long evolved strategies to shield themselves. For billions of years, bacteria hurled toxic molecules at each other in the struggle to prosper, and those that withstood the chemical onslaught marched on. Now, with an upti...

Dividing cells find their middle by following a protein 'contour map'

Self-organization keeps schools of fish, flocks of birds and colonies of termites in sync. It’s also, according to new research, the way cells regulate the final stage of cell division. Scientists at Rockefeller University have shown that a protein-chemistry-based contour map, which helps individ...

Celestial clues hint at eclipse in Homer's Odyssey

Among countless other debates about Homer’s Odyssey — not the least of which is whether the entire poem can be attributed to Homer himself — is whether Odysseus returns home to experience a total solar eclipse. Total eclipses, when the moon briefly but completely blocks the sun, happen prett...

Scientists identify a key regulator of DNA mutations

As a general rule, your DNA is not something you want rearranged. But there are exceptions – especially when it comes to fighting infections. Since the number of microbes in the world far surpasses the amount of human DNA dedicated to combat them, specialized cells in the immune system have adopt...

Flow of potassium ions in brain cells is key to sexual arousal

When it comes to sex, a female rat knows how to avoid a communication breakdown. To announce her sexual readiness, she will automatically arch her back, deflect her tail and stand rigid to allow an aroused male to mount. Now, Rockefeller University researchers have figured out the precise chemica...

Scientists image a single HIV particle being born

A mapmaker and a mathematician may seem like an unlikely duo, but together they worked out a way to measure longitude — and kept millions of sailors from getting lost at sea. Now, another unlikely duo, a virologist and a biophysicist at Rockefeller University, is making history of its own. By usi...

World Science Festival begins May 28

The first annual World Science Festival, an unprecedented celebration of scientific discovery sponsored in part by Rockefeller University and featuring more than a dozen Nobel laureates along with researchers, technologists, educators, policy makers, artists and performers, will begin May 28 in N...

DNA vaccines get a boost from dendritic cells

The concept sounds ideal: vaccines made of DNA that could be taken in by other cells and give instructions for how to fight off different diseases. The reality, however, has fallen short. Although DNA vaccines have been around for about 15 years and shown lots of promise for HIV, SARS and influen...

First evidence of native dendritic cells in brain

In a finding that has the potential to change the way researchers think about the brain, scientists at Rockefeller University have found dendritic cells where they’ve never been seen before: among this organ’s neurons and connective cells. The immunity-directing dendritic cell had previously bee...