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Structural study of anthrax yields new antibiotic target

Researchers studying anthrax knew they were onto something when they discovered an opponent the bacterium couldn’t outwit. Probing a bit deeper, they discovered this was because the attacker was interacting with something anthrax requires to survive: a carbohydrate in its cell wall. Now, in a stu...

Protein that controls hair growth also keeps stem cells slumbering

Like fine china and crystal, which tend to be used sparingly, stem cells divide infrequently. It was thought they did so to protect themselves from unnecessary wear and tear. But now new research from Rockefeller University has unveiled the protein that puts the brakes on stem cell division and s...

Protein discovered that prevents HIV from spreading

In a study that could open up the field of virology to an entirely new suite of possibilities and that paves the way for future drug research, scientists at Rockefeller University and the Aaron Diamond AIDS Research Center have pinned down a molecule on the surface of human cells that helps keep ...

Mammalian protein plays unexpected role in cell division, and perhaps cancer

The French Nobel laureate Jacques Monod famously said, “What’s true for E.coli is true for an elephant.” With this in mind, researchers at Rockefeller University set out to determine the function of Tel2, a protein originally found in yeast where it maintains the length of chromosome tips ca...

New model of a nuclear pore complex is based on crystal structure of its key component

Everything that goes in and out of a cell’s nucleus must pass through one of its nuclear pores. In the second nuclear pore study to come out of Rockefeller University in as many months, researchers have determined the crystal structure of one of the pore’s main components and used it to propose ...

Altering the balance of immune-cell receptors could help treat cancer and autoimmune diseases

Dendritic cells are responsible for directing the body’s immune response, and they’re activated through receptors on their surfaces. Now, in research that may have implications for novel disease therapies, Rockefeller University scientists have shown that the balance of two different versions of...

Two forces of arousal converge on the "satiety center" of the brain

By pitting two forces — hunger and circadian rhythms — against each other, researchers at Rockefeller University have identified the region of the brain that first registers changes in food availability. The research, in mice, suggests that shifting the timing of a meal increases mental alertnes...

New method enables scientists to see smells

Animals and insects communicate through an invisible world of scents. By exploiting infrared technology, researchers at Rockefeller University just made that world visible. With the ability to see smells, these scientists now show that when fly larvae detect smells with both olfactory organs they...

Active mechanism locks in the size of cell's nucleus

Cells know that size matters, especially when it comes to the nucleus. In the early 1900s, German scientists first proposed that the size of a nucleus is always proportional to the size of its cell. Now, more than a century later, researchers at Rockefeller University show that an active mechanis...

Most carriers of Fanconi anemia genes are not at a higher risk of cancer

For almost 50 years, Fanconi anemia has been associated with leukemia. Not just among those who have the genetic disorder but among their family members, whose genes, they were told, made them highly susceptible to a variety of malignancies. But a new study to examine links between 13 specific Fa...