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Understanding ubiquitylation: Researchers identify a process that enables access to genes

It turns out there’s more than one way to skin a gene. New research from Rockefeller University suggests that two closely related DNA unpackaging mechanisms may not work the way scientists thought. Access to a gene requires a host of proteins to work in tandem to pry open DNA’s protective chrom...
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New glimpse into early brain development shows how nerve cells move into position

Tucked into the lower, rear portion of the brain, the cerebellum plays key roles in motor learning, motor memory and sensory perception. It’s also where the majority of metastatic childhood brain tumors are located. Yet scientists still know very little about its early growth. Now, new research h...
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Immune response to cancer stem cells may dictate cancer's course

Although stem cells hold incredible promise in the fight against certain diseases, in cancer they’re anything but helpful. In fact, mounting evidence is showing that a tumor’s growth and spread may depend on “cancer stem cells,” which comprise only a very small subset of the tumor. Now, a ne...
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Humans, flies smell alike, neurobiologists find

The nose knows – whether it’s on a fruit fly or a human. And while it would seem that how a fruit fly judges odors should differ from how a human smells, new research from Rockefeller University finds that at the neurobiological level, the two organisms have more in common than one might expect....
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Viral protein is an effective preventative against infection

For parents, eight million cases of acute middle-ear infections every year add up to a lot of sleepless nights and trips to the pediatrician. But new research from a collaboration between Rockefeller University and St. Jude Children’s Research Hospital could change all that. Research in mice sugg...
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Chemical cues turn embryonic stem cells into cerebellar neurons

Embryonic stem cells have shown a great deal of promise for alleviating heart disease and regenerating organs. But for some of the conditions for which people hold out the most hope — Alzheimer’s and Parkinson’s, for example — there’s been little evidence to date that stem cells can work. ...
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For dying cells, timing is everything

Conventional wisdom suggests that cells are at all times balanced precariously between life and death, with proteins that could kill the cell poised to strike at a moment’s notice. While this is certainly true in some cases, new research from Rockefeller University shows that it is not universal,...
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New therapeutic target for Alzheimer's could lead to drugs without side effects

It’s been 100 years since Alzheimer’s disease was first described, and yet our best treatments in development for the disease are still highly toxic drugs. But new research from Rockefeller University, published in the February 26 online edition of Proceedings of the National Academy of Science...
Science News

Kety protein for Hepatitis C entry identified

For as many as 200 million people worldwide infected with hepatitis C, a leading cause of chronic liver disease, treatment options are only partially effective. But new research by Rockefeller University scientists points to a potential new target for better drugs: a key protein that resides in h...
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Sex hormone signaling helps burn calories

Any dieter can tell you: Body weight is a function of how much food you eat and how much energy you use. The trick to maintaining a healthy weight lies in regulating the balance. Now new research from Rockefeller University suggests that brain cell receptors linked to sex hormones may play a role...
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