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Science News

DNA breaks may help parasites elude the immune system

Parasites have spent millions of years of evolution trying to outsmart the human immune system, and one of their tricks is to change their appearance so that the immune cells no longer recognize them. In the parasite Trypanosoma brucei, which causes African sleeping sickness, new research suggest...
Science News

Dendritic cell receptor may be the key to an HIV vaccine

HIV vaccine science has hit a bit of a wall. For a vaccine to be really effective, it should be able to recruit different areas of the immune system. It should get one set of immune cells, called helper T cells, to recognize the AIDS virus and spur on another set of immune cells, the killer T cel...
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Preparing a multi-pronged attach: Different subsets of dendritic cells help expand the immune system's response

Dendritic cells coordinate and direct the body’s immune response, playing a crucial role in our ability to fend off disease. By processing molecules from invading pathogens — called antigens — they can present those molecules for other immune cells to recognize and attack. But researchers have...
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Researcher discover new cell death program

Cell death during animal development acts like an eraser — sculpting organs, the nervous system, fingers and toes — by removing unnecessary or unneeded cells. There are a few different processes that regulate how and when cells die, but research from Rockefeller University identifies a new type ...
Science News

Plant 'vaccines' may combat viruses in crops

Plants might not get colds, but they do get viruses — and viral diseases in crops cause enormous economic damage each year. New research, however, suggests that plant “vaccines,” developed at Rockefeller University, may be a new way of helping fend off viral attackers. “Plants possess sever...
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Viral detectives: Researchers track down the location of HIV-1 assembly in human cells

Since HIV was discovered in the early 1980s, scanning electron microscopes have been capturing images of the virus associated with different membranes of the cell they’ve infected. They can be seen stuck to the cell’s outer plasma membrane, as well as within membrane-enclosed structures called e...
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Unfolded proteins may protect cells from dying

When cells get stressed, their proteins go unfolded. It’s a reaction with a straightforward name: the unfolded protein response. Now, new research from Rockefeller University shows that this phenomenon actually serves a protective role; rather than a sign that the cells have given up, it may be a...
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Cellular pathway yields potential new weapon in vaccine arsenal

When a cell has to destroy any of its organelles or protein aggregates, it envelopes them in a membrane, forming an autophagosome, and then moves them to another compartment, the lysosome, for digestion. Two years ago, Rockefeller University assistant professor Christian Münz showed that this pro...
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Newborns could benefit from time away from home, rodent study suggests

First-time parents face an array of choices, each one seemingly vital for a newborn’s developing body and brain: cloth or disposable diapers? Breast milk or formula? Nanny or daycare? New research from neurobiologists at Rockefeller University may have something to say about that last question, s...
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A master repressor protein, Tcf3, holds stem cells back until the time is right

For stem cells, timing is key: To maintain their versatility they rely on a molecular mechanism that keeps the cells in a state of self-renewal until they are needed by adjacent tissue. Now, new research by Rockefeller University’s Elaine Fuchs reveals that in skin, the Tcf3 protein is a critical...
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